Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | NEDD8 | neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (81 aa) | ||
 | ZC3H14 | zinc finger CCCH-type containing 14 (736 aa) | ||
 | RPS16 | ribosomal protein S16 (146 aa) | ||
 | NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (866 aa) | ||
 | RPS23 | ribosomal protein S23 (143 aa) | ||
 | PNMA1 | paraneoplastic Ma antigen 1 (353 aa) | ||
 | WDR4 | WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit (412 aa) | ||
 | TPH2 | tryptophan hydroxylase 2 (490 aa) | ||
 | MRPL40 | mitochondrial ribosomal protein L40 (206 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | RPL9 | ribosomal protein L9 (192 aa) | ||
 | RPLP1 | ribosomal protein, large, P1; Plays an important role in the elongation step of protein synthesis (114 aa) | ||
 | RPL22L1 | ribosomal protein L22-like 1 (122 aa) | ||
 | RPL12 | ribosomal protein L12; Binds directly to 26S ribosomal RNA (By similarity) (165 aa) | ||
 | PSAT1 | phosphoserine aminotransferase 1; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) (370 aa) | ||
 | DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruit [...] (621 aa) | ||
 | NAA16 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit; May belong to a complex displaying N-terminal acetyltransferase activity (By similarity) (864 aa) | ||
 | RPS6 | ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (249 aa) | ||
 | ASMTL | acetylserotonin O-methyltransferase-like; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity (621 aa) | ||
 | MRPL2 | mitochondrial ribosomal protein L2 (305 aa) | ||
 | RPL24 | ribosomal protein L24 (157 aa) | ||
 | RPL34 | ribosomal protein L34 (117 aa) | ||
 | RPL37A | ribosomal protein L37a (92 aa) | ||
 | CLINT1 | clathrin interactor 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (643 aa) | ||
 | TDO2 | tryptophan 2,3-dioxygenase; Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity) (406 aa) | ||
 | RPS19 | ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits (145 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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