node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP1 | IL33 | ENSP00000410076 | ENSP00000370842 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | interleukin 33; Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury | 0.902 |
CASP1 | UBC | ENSP00000410076 | ENSP00000344818 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | ubiquitin C | 0.697 |
HIST1H2AG | HIST1H2BC | ENSP00000352119 | ENSP00000321744 | histone cluster 1, H2ag | histone cluster 1, H2bc | 0.899 |
HIST1H2AG | IL33 | ENSP00000352119 | ENSP00000370842 | histone cluster 1, H2ag | interleukin 33; Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury | 0.566 |
HIST1H2AG | UBC | ENSP00000352119 | ENSP00000344818 | histone cluster 1, H2ag | ubiquitin C | 0.689 |
HIST1H2AM | HIST1H2BC | ENSP00000352627 | ENSP00000321744 | histone cluster 1, H2am; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | histone cluster 1, H2bc | 0.890 |
HIST1H2AM | IL33 | ENSP00000352627 | ENSP00000370842 | histone cluster 1, H2am; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | interleukin 33; Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury | 0.566 |
HIST1H2AM | UBC | ENSP00000352627 | ENSP00000344818 | histone cluster 1, H2am; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | ubiquitin C | 0.696 |
HIST1H2BC | HIST1H2AG | ENSP00000321744 | ENSP00000352119 | histone cluster 1, H2bc | histone cluster 1, H2ag | 0.899 |
HIST1H2BC | HIST1H2AM | ENSP00000321744 | ENSP00000352627 | histone cluster 1, H2bc | histone cluster 1, H2am; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | 0.890 |
HIST1H2BC | HIST2H2AA3 | ENSP00000321744 | ENSP00000358158 | histone cluster 1, H2bc | histone cluster 2, H2aa3 | 0.879 |
HIST1H2BC | IL33 | ENSP00000321744 | ENSP00000370842 | histone cluster 1, H2bc | interleukin 33; Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury | 0.566 |
HIST1H2BC | UBC | ENSP00000321744 | ENSP00000344818 | histone cluster 1, H2bc | ubiquitin C | 0.716 |
HIST2H2AA3 | HIST1H2BC | ENSP00000358158 | ENSP00000321744 | histone cluster 2, H2aa3 | histone cluster 1, H2bc | 0.879 |
HIST2H2AA3 | IL33 | ENSP00000358158 | ENSP00000370842 | histone cluster 2, H2aa3 | interleukin 33; Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury | 0.574 |
HIST2H2AA3 | UBC | ENSP00000358158 | ENSP00000344818 | histone cluster 2, H2aa3 | ubiquitin C | 0.973 |
HIST2H2AA3 | USP21 | ENSP00000358158 | ENSP00000289865 | histone cluster 2, H2aa3 | ubiquitin specific peptidase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at ’Lys-4’, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates | 0.569 |
IL1RL1 | IL33 | ENSP00000233954 | ENSP00000370842 | interleukin 1 receptor-like 1; Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function | interleukin 33; Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury | 0.998 |
IL33 | CASP1 | ENSP00000370842 | ENSP00000410076 | interleukin 33; Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | 0.902 |
IL33 | HIST1H2AG | ENSP00000370842 | ENSP00000352119 | interleukin 33; Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury | histone cluster 1, H2ag | 0.566 |