| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARRB1 | GNA11 | ENSP00000409581 | ENSP00000078429 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.477 |
| CCDC88B | GNA11 | ENSP00000349238 | ENSP00000078429 | coiled-coil domain containing 88B | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.550 |
| CCDC88B | GNA14 | ENSP00000349238 | ENSP00000365807 | coiled-coil domain containing 88B | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.449 |
| CCDC88B | GNA15 | ENSP00000349238 | ENSP00000262958 | coiled-coil domain containing 88B | guanine nucleotide binding protein (G protein), alpha 15 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.449 |
| GNA11 | ARRB1 | ENSP00000078429 | ENSP00000409581 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | 0.477 |
| GNA11 | CCDC88B | ENSP00000078429 | ENSP00000349238 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | coiled-coil domain containing 88B | 0.550 |
| GNA11 | GNA12 | ENSP00000078429 | ENSP00000275364 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.567 |
| GNA11 | GNA14 | ENSP00000078429 | ENSP00000365807 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.900 |
| GNA11 | GNA15 | ENSP00000078429 | ENSP00000262958 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | guanine nucleotide binding protein (G protein), alpha 15 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.903 |
| GNA11 | GNAO1 | ENSP00000078429 | ENSP00000262493 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | 0.903 |
| GNA11 | SAG | ENSP00000078429 | ENSP00000386444 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | S-antigen; retina and pineal gland (arrestin); Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase | 0.555 |
| GNA12 | GNA11 | ENSP00000275364 | ENSP00000078429 | guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.567 |
| GNA12 | GNA14 | ENSP00000275364 | ENSP00000365807 | guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.551 |
| GNA12 | GNA15 | ENSP00000275364 | ENSP00000262958 | guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | guanine nucleotide binding protein (G protein), alpha 15 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.556 |
| GNA12 | GNAO1 | ENSP00000275364 | ENSP00000262493 | guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | 0.550 |
| GNA14 | CCDC88B | ENSP00000365807 | ENSP00000349238 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | coiled-coil domain containing 88B | 0.449 |
| GNA14 | GNA11 | ENSP00000365807 | ENSP00000078429 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.900 |
| GNA14 | GNA12 | ENSP00000365807 | ENSP00000275364 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.551 |
| GNA14 | GNA15 | ENSP00000365807 | ENSP00000262958 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | guanine nucleotide binding protein (G protein), alpha 15 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.901 |
| GNA14 | GNAO1 | ENSP00000365807 | ENSP00000262493 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | 0.902 |
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