node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPR143 | MLANA | ENSP00000417161 | ENSP00000370880 | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | melan-A; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes | 0.860 |
ITCH | MLANA | ENSP00000363998 | ENSP00000370880 | itchy E3 ubiquitin protein ligase | melan-A; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes | 0.811 |
ITCH | UBC | ENSP00000363998 | ENSP00000344818 | itchy E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
MLANA | GPR143 | ENSP00000370880 | ENSP00000417161 | melan-A; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | 0.860 |
MLANA | ITCH | ENSP00000370880 | ENSP00000363998 | melan-A; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes | itchy E3 ubiquitin protein ligase | 0.811 |
MLANA | NEDD4 | ENSP00000370880 | ENSP00000345530 | melan-A; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.818 |
MLANA | UBC | ENSP00000370880 | ENSP00000344818 | melan-A; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes | ubiquitin C | 0.576 |
NEDD4 | MLANA | ENSP00000345530 | ENSP00000370880 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | melan-A; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes | 0.818 |
NEDD4 | UBC | ENSP00000345530 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
UBC | ITCH | ENSP00000344818 | ENSP00000363998 | ubiquitin C | itchy E3 ubiquitin protein ligase | 0.999 |
UBC | MLANA | ENSP00000344818 | ENSP00000370880 | ubiquitin C | melan-A; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes | 0.576 |
UBC | NEDD4 | ENSP00000344818 | ENSP00000345530 | ubiquitin C | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.999 |