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MRPL51 MRPL51 TP53I3 TP53I3 MRPL52 MRPL52 MRPL28 MRPL28 MRPL10 MRPL10 MRPL55 MRPL55 MRPL42 MRPL42 OXA1L OXA1L ICT1 ICT1 MRPL38 MRPL38 USP44 USP44 MRPL23 MRPL23 MRPL13 MRPL13 MRPL3 MRPL3 MRPL49 MRPL49 MRPS14 MRPS14 MRPL27 MRPL27 MRPL1 MRPL1 PEBP1 PEBP1 MRPL11 MRPL11 MRPL15 MRPL15 MRPL41 MRPL41 PPT2 PPT2 MRPL4 MRPL4 MRPL47 MRPL47 RPL23 RPL23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MRPL28mitochondrial ribosomal protein L28 (256 aa)
MRPL27mitochondrial ribosomal protein L27 (148 aa)
MRPL51mitochondrial ribosomal protein L51 (128 aa)
TP53I3tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) (332 aa)
MRPL4mitochondrial ribosomal protein L4 (311 aa)
USP44ubiquitin specific peptidase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a neg [...] (712 aa)
MRPL15mitochondrial ribosomal protein L15 (296 aa)
PEBP1phosphatidylethanolamine binding protein 1; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (187 aa)
MRPL3mitochondrial ribosomal protein L3 (348 aa)
MRPL49mitochondrial ribosomal protein L49 (166 aa)
OXA1Loxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria (495 aa)
MRPL10mitochondrial ribosomal protein L10 (271 aa)
ICT1immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (206 aa)
MRPL13mitochondrial ribosomal protein L13 (178 aa)
MRPL38mitochondrial ribosomal protein L38 (380 aa)
MRPL11mitochondrial ribosomal protein L11 (192 aa)
MRPL1mitochondrial ribosomal protein L1 (325 aa)
MRPL52mitochondrial ribosomal protein L52 (123 aa)
PPT2palmitoyl-protein thioesterase 2 (308 aa)
MRPL55mitochondrial ribosomal protein L55 (164 aa)
MRPL41mitochondrial ribosomal protein L41; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
MRPL23mitochondrial ribosomal protein L23 (153 aa)
RPL23ribosomal protein L23 (140 aa)
MRPL47mitochondrial ribosomal protein L47 (250 aa)
MRPS14mitochondrial ribosomal protein S14 (128 aa)
MRPL42mitochondrial ribosomal protein L42 (142 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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