Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | CD4 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts (458 aa) | ||
 | CSK | c-src tyrosine kinase; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter p [...] (450 aa) | ||
 | MBOAT7 | membrane bound O-acyltransferase domain containing 7 (472 aa) | ||
 | COG3 | component of oligomeric golgi complex 3; Involved in ER-Golgi transport (828 aa) | ||
 | CD80 | CD80 molecule; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor (288 aa) | ||
 | COG5 | component of oligomeric golgi complex 5; Required for normal Golgi function (By similarity) (860 aa) | ||
 | COG1 | component of oligomeric golgi complex 1; Required for normal Golgi function (By similarity) (980 aa) | ||
 | CD3D | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction (171 aa) | ||
 | COG7 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) (770 aa) | ||
 | COG4 | component of oligomeric golgi complex 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (789 aa) | ||
 | PDCD1 | programmed cell death 1; Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors (288 aa) | ||
 | LCK | lymphocyte-specific protein tyrosine kinase (509 aa) | ||
 | PTPN11 | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity (593 aa) | ||
 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 (266 aa) | ||
 | CD3E | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction (207 aa) | ||
 | HLA-DQA2 | major histocompatibility complex, class II, DQ alpha 2 (255 aa) | ||
 | HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 (266 aa) | ||
 | CD274 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production (290 aa) | ||
 | HLA-DRA | major histocompatibility complex, class II, DR alpha (254 aa) | ||
 | PDCD1LG2 | programmed cell death 1 ligand 2; Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity) (273 aa) | ||
 | PTPN6 | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis (624 aa) | ||
 | HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 (260 aa) | ||
 | ENSG00000223931 | annotation not available (97 aa) | ||
 | ENSG00000228325 | Uncharacterized protein (130 aa) | ||
 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 (258 aa) | ||
 | CD3G | CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction (182 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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