node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPS15L1 | UBC | ENSP00000248070 | ENSP00000344818 | epidermal growth factor receptor pathway substrate 15-like 1; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 | ubiquitin C | 0.999 |
EPS15L1 | ZZEF1 | ENSP00000248070 | ENSP00000371051 | epidermal growth factor receptor pathway substrate 15-like 1; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 | zinc finger, ZZ-type with EF-hand domain 1 | 0.408 |
HECTD3 | NCAPH | ENSP00000361245 | ENSP00000240423 | HECT domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity) | non-SMC condensin I complex, subunit H; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity) | 0.538 |
HECTD3 | UBC | ENSP00000361245 | ENSP00000344818 | HECT domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity) | ubiquitin C | 0.782 |
HECTD3 | ZZEF1 | ENSP00000361245 | ENSP00000371051 | HECT domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity) | zinc finger, ZZ-type with EF-hand domain 1 | 0.538 |
LMNB1 | NCAPH | ENSP00000261366 | ENSP00000240423 | lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin | non-SMC condensin I complex, subunit H; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity) | 0.519 |
LMNB1 | UBC | ENSP00000261366 | ENSP00000344818 | lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin | ubiquitin C | 0.971 |
LMNB1 | ZZEF1 | ENSP00000261366 | ENSP00000371051 | lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin | zinc finger, ZZ-type with EF-hand domain 1 | 0.522 |
MAD1L1 | UBC | ENSP00000265854 | ENSP00000344818 | MAD1 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding | ubiquitin C | 0.798 |
MAD1L1 | ZZEF1 | ENSP00000265854 | ENSP00000371051 | MAD1 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding | zinc finger, ZZ-type with EF-hand domain 1 | 0.403 |
MYCBP | UBC | ENSP00000380702 | ENSP00000344818 | c-myc binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | ubiquitin C | 0.795 |
MYCBP | ZZEF1 | ENSP00000380702 | ENSP00000371051 | c-myc binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | zinc finger, ZZ-type with EF-hand domain 1 | 0.403 |
NCAPH | HECTD3 | ENSP00000240423 | ENSP00000361245 | non-SMC condensin I complex, subunit H; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity) | HECT domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity) | 0.538 |
NCAPH | LMNB1 | ENSP00000240423 | ENSP00000261366 | non-SMC condensin I complex, subunit H; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity) | lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin | 0.519 |
NCAPH | UBC | ENSP00000240423 | ENSP00000344818 | non-SMC condensin I complex, subunit H; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity) | ubiquitin C | 0.857 |
NCAPH | ZZEF1 | ENSP00000240423 | ENSP00000371051 | non-SMC condensin I complex, subunit H; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity) | zinc finger, ZZ-type with EF-hand domain 1 | 0.548 |
S100A4 | UBC | ENSP00000346294 | ENSP00000344818 | S100 calcium binding protein A4 | ubiquitin C | 0.807 |
UBC | EPS15L1 | ENSP00000344818 | ENSP00000248070 | ubiquitin C | epidermal growth factor receptor pathway substrate 15-like 1; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 | 0.999 |
UBC | HECTD3 | ENSP00000344818 | ENSP00000361245 | ubiquitin C | HECT domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity) | 0.782 |
UBC | LMNB1 | ENSP00000344818 | ENSP00000261366 | ubiquitin C | lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin | 0.971 |