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KCNC2 KCNC2 KCNS2 KCNS2 KCND3 KCND3 KCNG2 KCNG2 KCNG4 KCNG4 KCNC4 KCNC4 KCNA4 KCNA4 KCNA2 KCNA2 KCNA10 KCNA10 KCNA7 KCNA7 KCNQ3 KCNQ3 KCNQ1 KCNQ1 KCNA1 KCNA1 KCND2 KCND2 KCNS1 KCNS1 KCNQ5 KCNQ5 KCNS3 KCNS3 KCNAB2 KCNAB2 KCNQ2 KCNQ2 KCNV2 KCNV2 KCNAB1 KCNAB1 KCNG1 KCNG1 KCNB2 KCNB2 KCNAB3 KCNAB3 KCNA3 KCNA3 KCNC3 KCNC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] (676 aa)
KCNA7potassium voltage-gated channel, shaker-related subfamily, member 7; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity) (456 aa)
KCNS2potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (477 aa)
KCNAB3potassium voltage-gated channel, shaker-related subfamily, beta member 3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 (404 aa)
KCNS3potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (491 aa)
KCNS1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (526 aa)
KCNG4potassium voltage-gated channel, subfamily G, member 4; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (519 aa)
KCNA2potassium voltage-gated channel, shaker-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (499 aa)
KCNG2potassium voltage-gated channel, subfamily G, member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (466 aa)
KCND3potassium voltage-gated channel, Shal-related subfamily, member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (655 aa)
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 4; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (653 aa)
KCND2potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (630 aa)
KCNQ5potassium voltage-gated channel, KQT-like subfamily, member 5 (951 aa)
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 2 (872 aa)
KCNA3potassium voltage-gated channel, shaker-related subfamily, member 3; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (575 aa)
KCNA10potassium voltage-gated channel, shaker-related subfamily, member 10; Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP (511 aa)
KCNC4potassium voltage-gated channel, Shaw-related subfamily, member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (635 aa)
KCNG1potassium voltage-gated channel, subfamily G, member 1; Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity (513 aa)
KCNAB2potassium voltage-gated channel, shaker-related subfamily, beta member 2 (415 aa)
KCNV2potassium channel, subfamily V, member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (545 aa)
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia); Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (495 aa)
KCNQ3potassium voltage-gated channel, KQT-like subfamily, member 3; Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (872 aa)
KCNAB1potassium voltage-gated channel, shaker-related subfamily, beta member 1 (419 aa)
KCNB2potassium voltage-gated channel, Shab-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient (911 aa)
KCNC3potassium voltage-gated channel, Shaw-related subfamily, member 3; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (757 aa)
KCNC2potassium voltage-gated channel, Shaw-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly (By similarity) (638 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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