node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOX2 | AMACR | ENSP00000307697 | ENSP00000371517 | acyl-CoA oxidase 2, branched chain; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids | alpha-methylacyl-CoA racemase | 0.976 |
ACOX2 | PEX5 | ENSP00000307697 | ENSP00000407401 | acyl-CoA oxidase 2, branched chain; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.819 |
ACOX3 | AMACR | ENSP00000348775 | ENSP00000371517 | acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) | alpha-methylacyl-CoA racemase | 0.974 |
ACOX3 | PEX5 | ENSP00000348775 | ENSP00000407401 | acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.778 |
ACOX3 | UBC | ENSP00000348775 | ENSP00000344818 | acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) | ubiquitin C | 0.525 |
AMACR | ACOX2 | ENSP00000371517 | ENSP00000307697 | alpha-methylacyl-CoA racemase | acyl-CoA oxidase 2, branched chain; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids | 0.976 |
AMACR | ACOX3 | ENSP00000371517 | ENSP00000348775 | alpha-methylacyl-CoA racemase | acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) | 0.974 |
AMACR | PEX5 | ENSP00000371517 | ENSP00000407401 | alpha-methylacyl-CoA racemase | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.479 |
AMACR | SLC27A5 | ENSP00000371517 | ENSP00000263093 | alpha-methylacyl-CoA racemase | solute carrier family 27 (fatty acid transporter), member 5; Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol | 0.912 |
AMACR | UBC | ENSP00000371517 | ENSP00000344818 | alpha-methylacyl-CoA racemase | ubiquitin C | 0.506 |
PEX5 | ACOX2 | ENSP00000407401 | ENSP00000307697 | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | acyl-CoA oxidase 2, branched chain; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids | 0.819 |
PEX5 | ACOX3 | ENSP00000407401 | ENSP00000348775 | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) | 0.778 |
PEX5 | AMACR | ENSP00000407401 | ENSP00000371517 | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | alpha-methylacyl-CoA racemase | 0.479 |
PEX5 | UBC | ENSP00000407401 | ENSP00000344818 | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | ubiquitin C | 0.919 |
SLC27A5 | AMACR | ENSP00000263093 | ENSP00000371517 | solute carrier family 27 (fatty acid transporter), member 5; Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol | alpha-methylacyl-CoA racemase | 0.912 |
UBC | ACOX3 | ENSP00000344818 | ENSP00000348775 | ubiquitin C | acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) | 0.525 |
UBC | AMACR | ENSP00000344818 | ENSP00000371517 | ubiquitin C | alpha-methylacyl-CoA racemase | 0.506 |
UBC | PEX5 | ENSP00000344818 | ENSP00000407401 | ubiquitin C | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.919 |