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HSCB | HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria (235 aa) | |||
NDFIP2 | Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling (336 aa) | |||
SGTA | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (313 aa) | |||
CAT | catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (527 aa) | |||
NDFIP1 | Nedd4 family interacting protein 1; Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through mult [...] (221 aa) | |||
SCLY | selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity) (453 aa) | |||
ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) (946 aa) | |||
SOD1 | superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (154 aa) | |||
CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like); May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (1036 aa) | |||
TKTL2 | transketolase-like 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (626 aa) | |||
HSPA9 | heat shock 70kDa protein 9 (mortalin) (679 aa) | |||
ATOX1 | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (68 aa) | |||
KDM4D | lysine (K)-specific demethylase 4D; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Demethylates both di- and trimethylated H3 ’Lys- 9’ residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (523 aa) | |||
FBLN5 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling (448 aa) | |||
ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (1001 aa) | |||
ATP2A3 | ATPase, Ca++ transporting, ubiquitous (1052 aa) | |||
SOD2 | superoxide dismutase 2, mitochondrial; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (222 aa) | |||
TKTL1 | transketolase-like 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity) (596 aa) | |||
NFS1 | NFS1 nitrogen fixation 1 homolog (S. cerevisiae); Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor (457 aa) | |||
SGTB | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (By similarity) (304 aa) | |||
SOD3 | superoxide dismutase 3, extracellular; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen (240 aa) | |||
GPX3 | glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione (226 aa) | |||
ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 (973 aa) | |||
KDM4E | lysine (K)-specific demethylase 4E; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code (506 aa) | |||
TKT | transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (623 aa) | |||
ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (1042 aa) |