Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
SGTA SGTA KDM4E KDM4E SCLY SCLY SGTB SGTB HSCB HSCB FBLN5 FBLN5 ATOX1 ATOX1 NFS1 NFS1 CRIM1 CRIM1 HSPA9 HSPA9 TKT TKT TKTL2 TKTL2 SOD3 SOD3 TKTL1 TKTL1 KDM4D KDM4D SOD1 SOD1 CAT CAT ATP2C2 ATP2C2 NDFIP2 NDFIP2 SOD2 SOD2 ATP2C1 ATP2C1 GPX3 GPX3 ATP2A3 ATP2A3 ATP2A1 ATP2A1 NDFIP1 NDFIP1 ATP2A2 ATP2A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
HSCBHscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria (235 aa)
NDFIP2Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling (336 aa)
SGTAsmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (313 aa)
CATcatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (527 aa)
NDFIP1Nedd4 family interacting protein 1; Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through mult [...] (221 aa)
SCLYselenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity) (453 aa)
ATP2C2ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) (946 aa)
SOD1superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (154 aa)
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like); May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (1036 aa)
TKTL2transketolase-like 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (626 aa)
HSPA9heat shock 70kDa protein 9 (mortalin) (679 aa)
ATOX1ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (68 aa)
KDM4Dlysine (K)-specific demethylase 4D; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Demethylates both di- and trimethylated H3 ’Lys- 9’ residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (523 aa)
FBLN5fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling (448 aa)
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (1001 aa)
ATP2A3ATPase, Ca++ transporting, ubiquitous (1052 aa)
SOD2superoxide dismutase 2, mitochondrial; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (222 aa)
TKTL1transketolase-like 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity) (596 aa)
NFS1NFS1 nitrogen fixation 1 homolog (S. cerevisiae); Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor (457 aa)
SGTBsmall glutamine-rich tetratricopeptide repeat (TPR)-containing, beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (By similarity) (304 aa)
SOD3superoxide dismutase 3, extracellular; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen (240 aa)
GPX3glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione (226 aa)
ATP2C1ATPase, Ca++ transporting, type 2C, member 1 (973 aa)
KDM4Elysine (K)-specific demethylase 4E; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code (506 aa)
TKTtransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (623 aa)
ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (1042 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (38%)