node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASNA1 | UBC | ENSP00000349887 | ENSP00000344818 | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] | ubiquitin C | 0.863 |
CLCN7 | LAMP2 | ENSP00000372193 | ENSP00000408411 | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens | 0.612 |
CLCN7 | OSTM1 | ENSP00000372193 | ENSP00000193322 | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) | 0.998 |
CLCN7 | PACS1 | ENSP00000372193 | ENSP00000316454 | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | phosphofurin acidic cluster sorting protein 1 | 0.615 |
CLCN7 | UBC | ENSP00000372193 | ENSP00000344818 | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | ubiquitin C | 0.740 |
LAMP2 | CLCN7 | ENSP00000408411 | ENSP00000372193 | lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | 0.612 |
OSTM1 | CLCN7 | ENSP00000193322 | ENSP00000372193 | osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | 0.998 |
OSTM1 | UBC | ENSP00000193322 | ENSP00000344818 | osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) | ubiquitin C | 0.802 |
PACS1 | CLCN7 | ENSP00000316454 | ENSP00000372193 | phosphofurin acidic cluster sorting protein 1 | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | 0.615 |
PACS1 | UBC | ENSP00000316454 | ENSP00000344818 | phosphofurin acidic cluster sorting protein 1 | ubiquitin C | 0.483 |
TMEM9 | UBC | ENSP00000356298 | ENSP00000344818 | transmembrane protein 9; May be involved in intracellular transport | ubiquitin C | 0.854 |
TMEM9B | UBC | ENSP00000433361 | ENSP00000344818 | TMEM9 domain family, member B | ubiquitin C | 0.795 |
UBC | ASNA1 | ENSP00000344818 | ENSP00000349887 | ubiquitin C | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] | 0.863 |
UBC | CLCN7 | ENSP00000344818 | ENSP00000372193 | ubiquitin C | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | 0.740 |
UBC | OSTM1 | ENSP00000344818 | ENSP00000193322 | ubiquitin C | osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) | 0.802 |
UBC | PACS1 | ENSP00000344818 | ENSP00000316454 | ubiquitin C | phosphofurin acidic cluster sorting protein 1 | 0.483 |
UBC | TMEM9 | ENSP00000344818 | ENSP00000356298 | ubiquitin C | transmembrane protein 9; May be involved in intracellular transport | 0.854 |
UBC | TMEM9B | ENSP00000344818 | ENSP00000433361 | ubiquitin C | TMEM9 domain family, member B | 0.795 |
UBC | UBQLN2 | ENSP00000344818 | ENSP00000345195 | ubiquitin C | ubiquilin 2; Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation | 0.998 |
UBQLN2 | UBC | ENSP00000345195 | ENSP00000344818 | ubiquilin 2; Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation | ubiquitin C | 0.998 |