26 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	HBQ1	hemoglobin, theta 1 (142 aa)
	ACADL	acyl-CoA dehydrogenase, long chain (430 aa)
	RDH10	retinol dehydrogenase 10 (all-trans); Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (341 aa)
	CDY2A	chromodomain protein, Y-linked, 2A; May have histone acetyltransferase activity (By similarity) (541 aa)
	ACAT1	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism (427 aa)
	MUT	methylmalonyl CoA mutase; Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (750 aa)
	DHRS12	dehydrogenase/reductase (SDR family) member 12; Putative oxidoreductase (By similarity) (271 aa)
	ACAA2	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1 (613 aa)
	CBR1	carbonyl reductase 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (277 aa)
	C2orf81	chromosome 2 open reading frame 81 (588 aa)
	HBE1	hemoglobin, epsilon 1; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin (147 aa)
	HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD); Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells (266 aa)
	HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (474 aa)
	ACAA1	acetyl-CoA acyltransferase 1 (424 aa)
	DHRSX	dehydrogenase/reductase (SDR family) X-linked (330 aa)
	HBG2	hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains (147 aa)
	ACACB	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
	ACACA	acetyl-CoA carboxylase alpha (2383 aa)
	ACAT2	acetyl-CoA acetyltransferase 2 (397 aa)
	PCCA	propionyl CoA carboxylase, alpha polypeptide (728 aa)
	RDH14	retinol dehydrogenase 14 (all-trans/9-cis/11-cis); Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected (336 aa)
	CDY2B	chromodomain protein, Y-linked, 2B; May have histone acetyltransferase activity (By similarity) (541 aa)
	PAICS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (432 aa)
	IVD	isovaleryl-CoA dehydrogenase (426 aa)
	ENSG00000255154	Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis (168 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACACA	ENSP00000333664	ENSP00000344789	acetyl-CoA acyltransferase 1	acetyl-CoA carboxylase alpha	0.854
ACAA1	ACACB	ENSP00000333664	ENSP00000341044	acetyl-CoA acyltransferase 1	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.807
ACAA1	ACADL	ENSP00000333664	ENSP00000233710	acetyl-CoA acyltransferase 1	acyl-CoA dehydrogenase, long chain	0.949
ACAA1	ACAT1	ENSP00000333664	ENSP00000265838	acetyl-CoA acyltransferase 1	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.924
ACAA1	ACAT2	ENSP00000333664	ENSP00000356015	acetyl-CoA acyltransferase 1	acetyl-CoA acetyltransferase 2	0.911
ACAA1	CDY2A	ENSP00000333664	ENSP00000250838	acetyl-CoA acyltransferase 1	chromodomain protein, Y-linked, 2A; May have histone acetyltransferase activity (By similarity)	0.767
ACAA1	CDY2B	ENSP00000333664	ENSP00000372319	acetyl-CoA acyltransferase 1	chromodomain protein, Y-linked, 2B; May have histone acetyltransferase activity (By similarity)	0.767
ACAA1	ENSG00000255154	ENSP00000333664	ENSP00000437142	acetyl-CoA acyltransferase 1	Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis	0.753
ACAA1	MUT	ENSP00000333664	ENSP00000274813	acetyl-CoA acyltransferase 1	methylmalonyl CoA mutase; Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species	0.504
ACAA1	PCCA	ENSP00000333664	ENSP00000365462	acetyl-CoA acyltransferase 1	propionyl CoA carboxylase, alpha polypeptide	0.920
ACAA2	ACACA	ENSP00000285093	ENSP00000344789	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	acetyl-CoA carboxylase alpha	0.809
ACAA2	ACACB	ENSP00000285093	ENSP00000341044	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.820
ACAA2	ACADL	ENSP00000285093	ENSP00000233710	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	acyl-CoA dehydrogenase, long chain	0.972
ACAA2	ACAT1	ENSP00000285093	ENSP00000265838	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.972
ACAA2	ACAT2	ENSP00000285093	ENSP00000356015	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	acetyl-CoA acetyltransferase 2	0.908
ACAA2	CDY2A	ENSP00000285093	ENSP00000250838	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	chromodomain protein, Y-linked, 2A; May have histone acetyltransferase activity (By similarity)	0.745
ACAA2	CDY2B	ENSP00000285093	ENSP00000372319	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	chromodomain protein, Y-linked, 2B; May have histone acetyltransferase activity (By similarity)	0.745
ACAA2	ENSG00000255154	ENSP00000285093	ENSP00000437142	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis	0.467
ACAA2	IVD	ENSP00000285093	ENSP00000418397	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	isovaleryl-CoA dehydrogenase	0.659
ACAA2	MUT	ENSP00000285093	ENSP00000274813	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	methylmalonyl CoA mutase; Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species	0.509

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