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STRINGSTRING
LIN28A LIN28A POP1 POP1 NCBP1 NCBP1 UBC UBC RPS15A RPS15A RPS15 RPS15 MRPS12 MRPS12 RPS13 RPS13 METTL17 METTL17 RPS2 RPS2 MRPS15 MRPS15 HIBCH HIBCH RPS5 RPS5 MRPS9 MRPS9 RPS20 RPS20 MRPS5 MRPS5 MRPS2 MRPS2 MRPS10 MRPS10 MRPS7 MRPS7 MRPS18C MRPS18C LRPPRC LRPPRC SOD2 SOD2 MRPS16 MRPS16 MRPS18A MRPS18A DAP3 DAP3 MRPS35 MRPS35
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MRPS10mitochondrial ribosomal protein S10 (201 aa)
MRPS35mitochondrial ribosomal protein S35 (323 aa)
RPS5ribosomal protein S5 (204 aa)
MRPS2mitochondrial ribosomal protein S2 (296 aa)
MRPS7mitochondrial ribosomal protein S7 (242 aa)
LIN28Alin-28 homolog A (C. elegans); Acts as a ’translational enhancer’, driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) [...] (209 aa)
MRPS9mitochondrial ribosomal protein S9 (396 aa)
LRPPRCleucine-rich pentatricopeptide repeat containing; May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondria [...] (1394 aa)
MRPS5mitochondrial ribosomal protein S5 (430 aa)
MRPS18Cmitochondrial ribosomal protein S18C (142 aa)
MRPS12mitochondrial ribosomal protein S12 (138 aa)
RPS15Aribosomal protein S15a (130 aa)
POP1processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP (1024 aa)
DAP3death associated protein 3; Involved in mediating interferon-gamma-induced cell death (398 aa)
RPS2ribosomal protein S2 (293 aa)
UBCubiquitin C (685 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (386 aa)
SOD2superoxide dismutase 2, mitochondrial; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (222 aa)
MRPS18Amitochondrial ribosomal protein S18A (196 aa)
MRPS16mitochondrial ribosomal protein S16 (137 aa)
MRPS15mitochondrial ribosomal protein S15 (257 aa)
NCBP1nuclear cap binding protein subunit 1, 80kDa; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5’-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5’-end of mRNA and to mRNA export in a 5’ to 3’ direction through the nuclear pore. T [...] (790 aa)
METTL17methyltransferase like 17; May be a component of the mitochondrial small ribosomal subunit (By similarity) (478 aa)
RPS20ribosomal protein S20 (142 aa)
RPS13ribosomal protein S13 (151 aa)
RPS15ribosomal protein S15 (145 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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