node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA1 | CCNB1 | ENSP00000255465 | ENSP00000256442 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.997 |
CCNA1 | CCNB2 | ENSP00000255465 | ENSP00000288207 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.971 |
CCNA2 | CCNB1 | ENSP00000274026 | ENSP00000256442 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.993 |
CCNA2 | CCNB2 | ENSP00000274026 | ENSP00000288207 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.972 |
CCNA2 | MYC | ENSP00000274026 | ENSP00000367207 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.461 |
CCNA2 | NEK2 | ENSP00000274026 | ENSP00000355966 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | NIMA-related kinase 2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex [...] | 0.522 |
CCNB1 | CCNA1 | ENSP00000256442 | ENSP00000255465 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | 0.997 |
CCNB1 | CCNA2 | ENSP00000256442 | ENSP00000274026 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | 0.993 |
CCNB1 | CCNB2 | ENSP00000256442 | ENSP00000288207 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.961 |
CCNB1 | CCNF | ENSP00000256442 | ENSP00000380256 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin F; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication | 0.839 |
CCNB1 | HSP90AA1 | ENSP00000256442 | ENSP00000335153 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.809 |
CCNB1 | HSP90AB1 | ENSP00000256442 | ENSP00000325875 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.743 |
CCNB1 | MYC | ENSP00000256442 | ENSP00000367207 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.996 |
CCNB1 | NEK2 | ENSP00000256442 | ENSP00000355966 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | NIMA-related kinase 2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex [...] | 0.631 |
CCNB2 | CCNA1 | ENSP00000288207 | ENSP00000255465 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | 0.971 |
CCNB2 | CCNA2 | ENSP00000288207 | ENSP00000274026 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | 0.972 |
CCNB2 | CCNB1 | ENSP00000288207 | ENSP00000256442 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.961 |
CCNB2 | CCNF | ENSP00000288207 | ENSP00000380256 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin F; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication | 0.614 |
CCNB2 | HSP90AA1 | ENSP00000288207 | ENSP00000335153 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.725 |
CCNB2 | HSP90AB1 | ENSP00000288207 | ENSP00000325875 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.720 |