adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

adrenoceptor alpha 2A; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

complement component 3a receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

cannabinoid receptor 1 (brain)

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

chemokine (C-X-C motif) ligand 11; Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

chemokine (C-X-C motif) receptor 5; Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

dopamine receptor D3; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

G protein-coupled estrogen receptor 1

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

hydroxycarboxylic acid receptor 2; Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and p [...]

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

heme binding protein 1; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N- methylprotoporphyrin with similar affinities

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

neuropeptides B/W receptor 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

oxoeicosanoid (OXE) receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

purinergic receptor P2Y, G-protein coupled, 14; Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet al [...]

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

Sphingosine 1-phosphate receptor 2 ; Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

sphingosine-1-phosphate receptor 3; Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis