Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
STX1A STX1A FAM161A FAM161A STX2 STX2 FAM9B FAM9B VAMP1 VAMP1 STX11 STX11 STX3 STX3 VAMP2 VAMP2 ENSG00000263620 ENSG00000263620 ZNF572 ZNF572 VAMP3 VAMP3 STX4 STX4 VAMP4 VAMP4 STX19 STX19 STX1B STX1B DMD DMD DRD2 DRD2 TTLL10 TTLL10 C19orf66 C19orf66 CADPS CADPS ARF1 ARF1 TCL1A TCL1A C17orf67 C17orf67 KIAA1549 KIAA1549
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
VAMP3vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network (100 aa)
STX1Bsyntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity) (288 aa)
STX1Asyntaxin 1A (brain) (288 aa)
VAMP4vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (141 aa)
C19orf66chromosome 19 open reading frame 66 (291 aa)
ARF1ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] (181 aa)
VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane (116 aa)
STX4syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones (297 aa)
FAM9Bfamily with sequence similarity 9, member B (186 aa)
ZNF572zinc finger protein 572; May be involved in transcriptional regulation (By similarity) (529 aa)
STX19syntaxin 19 (294 aa)
STX3syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones (289 aa)
DRD2dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) (443 aa)
DMDdystrophin (3685 aa)
STX11syntaxin 11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network (287 aa)
TTLL10tubulin tyrosine ligase-like family, member 10; Inactive polyglycylase (673 aa)
CADPSCa++-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small [...] (1353 aa)
STX2syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (288 aa)
VAMP1vesicle-associated membrane protein 1 (synaptobrevin 1); Involved in the targeting and/or fusion of transport vesicles to their target membrane (118 aa)
C17orf67chromosome 17 open reading frame 67 (114 aa)
TCL1AT-cell leukemia/lymphoma 1A; Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (114 aa)
FAM161Afamily with sequence similarity 161, member A; Involved in ciliogenesis (716 aa)
KIAA1549KIAA1549 (1950 aa)
ENSG00000263620Uncharacterized protein (121 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (40%)