| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACHE | COLQ | ENSP00000303211 | ENSP00000373298 | acetylcholinesterase | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 0.963 |
| ACHE | MUSK | ENSP00000303211 | ENSP00000363571 | acetylcholinesterase | muscle, skeletal, receptor tyrosine kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton an [...] | 0.659 |
| AMH | BMP4 | ENSP00000221496 | ENSP00000245451 | anti-Mullerian hormone; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.478 |
| BCHE | COLQ | ENSP00000264381 | ENSP00000373298 | butyrylcholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 0.891 |
| BMP4 | AMH | ENSP00000245451 | ENSP00000221496 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | anti-Mullerian hormone; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin | 0.478 |
| BMP4 | RBPJ | ENSP00000245451 | ENSP00000345206 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | recombination signal binding protein for immunoglobulin kappa J region; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of c [...] | 0.565 |
| BMP4 | RBPJL | ENSP00000245451 | ENSP00000341243 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | recombination signal binding protein for immunoglobulin kappa J region-like; Putative transcription factor, which cooperates with EBNA2 to activate transcription (By similarity) | 0.431 |
| BMP4 | UBC | ENSP00000245451 | ENSP00000344818 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | ubiquitin C | 0.402 |
| COLQ | ACHE | ENSP00000373298 | ENSP00000303211 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | acetylcholinesterase | 0.963 |
| COLQ | BCHE | ENSP00000373298 | ENSP00000264381 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | butyrylcholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters | 0.891 |
| COLQ | MUSK | ENSP00000373298 | ENSP00000363571 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | muscle, skeletal, receptor tyrosine kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton an [...] | 0.951 |
| COLQ | RBPJL | ENSP00000373298 | ENSP00000341243 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | recombination signal binding protein for immunoglobulin kappa J region-like; Putative transcription factor, which cooperates with EBNA2 to activate transcription (By similarity) | 0.436 |
| MUSK | ACHE | ENSP00000363571 | ENSP00000303211 | muscle, skeletal, receptor tyrosine kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton an [...] | acetylcholinesterase | 0.659 |
| MUSK | COLQ | ENSP00000363571 | ENSP00000373298 | muscle, skeletal, receptor tyrosine kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton an [...] | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 0.951 |
| MUSK | UBC | ENSP00000363571 | ENSP00000344818 | muscle, skeletal, receptor tyrosine kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton an [...] | ubiquitin C | 0.621 |
| PLOD1 | PLOD3 | ENSP00000196061 | ENSP00000223127 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links | 0.902 |
| PLOD1 | UBC | ENSP00000196061 | ENSP00000344818 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links | ubiquitin C | 0.737 |
| PLOD2 | PLOD3 | ENSP00000282903 | ENSP00000223127 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links | 0.902 |
| PLOD2 | UBC | ENSP00000282903 | ENSP00000344818 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links | ubiquitin C | 0.483 |
| PLOD3 | PLOD1 | ENSP00000223127 | ENSP00000196061 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links | 0.902 |
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