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KCNQ1 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] (676 aa) | |||
KCNA7 | potassium voltage-gated channel, shaker-related subfamily, member 7; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity) (456 aa) | |||
SPTBN4 | spectrin, beta, non-erythrocytic 4 (2564 aa) | |||
ANK1 | ankyrin 1, erythrocytic (1897 aa) | |||
KCNC1 | potassium voltage-gated channel, Shaw-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (585 aa) | |||
KCNA6 | potassium voltage-gated channel, shaker-related subfamily, member 6; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (529 aa) | |||
KCNS2 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (477 aa) | |||
KCNF1 | potassium voltage-gated channel, subfamily F, member 1; Putative voltage-gated potassium channel (494 aa) | |||
KCNV1 | potassium channel, subfamily V, member 1; Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (500 aa) | |||
KCNAB3 | potassium voltage-gated channel, shaker-related subfamily, beta member 3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 (404 aa) | |||
KCNG3 | potassium voltage-gated channel, subfamily G, member 3; Potassium channel subunit. Modulates channel activity (436 aa) | |||
KCNS3 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (491 aa) | |||
KCNS1 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (526 aa) | |||
SPTBN2 | spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton (2390 aa) | |||
KCNG4 | potassium voltage-gated channel, subfamily G, member 4; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (519 aa) | |||
SPTBN5 | spectrin, beta, non-erythrocytic 5 (3674 aa) | |||
KCND2 | potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (630 aa) | |||
NFASC | neurofascin (1240 aa) | |||
SPTBN1 | spectrin, beta, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane (2364 aa) | |||
ANK2 | ankyrin 2, neuronal; In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner se [...] (3957 aa) | |||
SPTA1 | spectrin, alpha, erythrocytic 1 (elliptocytosis 2); Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2419 aa) | |||
KCNA3 | potassium voltage-gated channel, shaker-related subfamily, member 3; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (575 aa) | |||
KCNA10 | potassium voltage-gated channel, shaker-related subfamily, member 10; Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP (511 aa) | |||
KCNC4 | potassium voltage-gated channel, Shaw-related subfamily, member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (635 aa) | |||
KCNG1 | potassium voltage-gated channel, subfamily G, member 1; Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity (513 aa) | |||
KCNQ3 | potassium voltage-gated channel, KQT-like subfamily, member 3; Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (872 aa) |