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GNAS GNAS ADCY5 ADCY5 ADCY7 ADCY7 ADCY9 ADCY9 ADCY3 ADCY3 ADCY2 ADCY2 ADCY4 ADCY4 ADCY8 ADCY8 ADCY6 ADCY6 GNAI3 GNAI3 MAP1A MAP1A MAPK13 MAPK13 RAPGEF3 RAPGEF3 RAPGEF4 RAPGEF4 RANBP2 RANBP2 MAPK12 MAPK12 KCNJ11 KCNJ11 MAPK11 MAPK11 MAPK14 MAPK14 ABCC8 ABCC8 RAP1B RAP1B RAF1 RAF1 APBB1IP APBB1IP RAP1GAP RAP1GAP SIPA1 SIPA1 RAP1GAP2 RAP1GAP2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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from curated databases
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experimentally determined
Predicted Interactions
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textmining
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Your Input:
MAPK13mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] (365 aa)
MAPK12mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...] (367 aa)
MAPK14mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
RAP1BRAP1B, member of RAS oncogene family (184 aa)
RAF1v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] (648 aa)
ADCY7adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1080 aa)
RAP1GAP2RAP1 GTPase activating protein 2; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state (730 aa)
ADCY3adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration (1144 aa)
RANBP2RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB (3224 aa)
ADCY8adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity) (1251 aa)
RAP1GAPRAP1 GTPase activating protein; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state (727 aa)
ADCY9adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) (1353 aa)
MAP1Amicrotubule-associated protein 1A; Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements (2803 aa)
ADCY6adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) (1168 aa)
ADCY4adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity) (1077 aa)
MAPK11mitogen-activated protein kinase 11; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MA [...] (364 aa)
ADCY2adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (1091 aa)
KCNJ11potassium inwardly-rectifying channel, subfamily J, member 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity) [...] (390 aa)
GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (354 aa)
GNASGNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) (1037 aa)
APBB1IPamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion (666 aa)
RAPGEF3Rap guanine nucleotide exchange factor (GEF) 3; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis (923 aa)
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 8; Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release (1581 aa)
SIPA1signal-induced proliferation-associated 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state (1042 aa)
RAPGEF4Rap guanine nucleotide exchange factor (GEF) 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity) (1011 aa)
ADCY5adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1261 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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