node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMOTL2 | UBC | ENSP00000249883 | ENSP00000344818 | angiomotin like 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC | ubiquitin C | 0.911 |
BET3L | TRAPPC10 | ENSP00000357591 | ENSP00000291574 | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | trafficking protein particle complex 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.934 |
BET3L | TRAPPC2 | ENSP00000357591 | ENSP00000392495 | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | trafficking protein particle complex 2; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.950 |
BET3L | TRAPPC4 | ENSP00000357591 | ENSP00000436005 | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | trafficking protein particle complex 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.914 |
BET3L | TRAPPC8 | ENSP00000357591 | ENSP00000283351 | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage | 0.934 |
BET3L | TRAPPC9 | ENSP00000357591 | ENSP00000373979 | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | trafficking protein particle complex 9 | 0.612 |
IKBKB | MAP4K4 | ENSP00000430684 | ENSP00000314363 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF- [...] | mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 | 0.998 |
IKBKB | TRAPPC9 | ENSP00000430684 | ENSP00000373979 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF- [...] | trafficking protein particle complex 9 | 0.708 |
IKBKB | UBC | ENSP00000430684 | ENSP00000344818 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF- [...] | ubiquitin C | 0.999 |
MAP4K4 | IKBKB | ENSP00000314363 | ENSP00000430684 | mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF- [...] | 0.998 |
MAP4K4 | TRAPPC9 | ENSP00000314363 | ENSP00000373979 | mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 | trafficking protein particle complex 9 | 0.576 |
MAP4K4 | UBC | ENSP00000314363 | ENSP00000344818 | mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 | ubiquitin C | 0.999 |
NOTCH1 | UBC | ENSP00000277541 | ENSP00000344818 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | ubiquitin C | 0.999 |
RAB3IP | TRAPPC10 | ENSP00000447300 | ENSP00000291574 | RAB3A interacting protein (rabin3) | trafficking protein particle complex 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.662 |
RAB3IP | TRAPPC2 | ENSP00000447300 | ENSP00000392495 | RAB3A interacting protein (rabin3) | trafficking protein particle complex 2; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.622 |
RAB3IP | TRAPPC2L | ENSP00000447300 | ENSP00000301021 | RAB3A interacting protein (rabin3) | trafficking protein particle complex 2-like; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.574 |
RAB3IP | TRAPPC3 | ENSP00000447300 | ENSP00000362261 | RAB3A interacting protein (rabin3) | trafficking protein particle complex 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.727 |
RAB3IP | TRAPPC4 | ENSP00000447300 | ENSP00000436005 | RAB3A interacting protein (rabin3) | trafficking protein particle complex 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.626 |
RAB3IP | TRAPPC9 | ENSP00000447300 | ENSP00000373979 | RAB3A interacting protein (rabin3) | trafficking protein particle complex 9 | 0.626 |
TRAPPC10 | BET3L | ENSP00000291574 | ENSP00000357591 | trafficking protein particle complex 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | 0.934 |