11 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Your Input:
	HLA-F	major histocompatibility complex, class I, F (442 aa)
	ANGPTL5	angiopoietin-like 5 (388 aa)
	HLA-G	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells (338 aa)
	FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64) (374 aa)
	ANGPTL2	angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action (493 aa)
	HLA-C	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) (366 aa)
	HLA-A	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity) (365 aa)
	LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (598 aa)
	PTPN6	protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis (624 aa)
	HLA-B	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity) (362 aa)
	B2M	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) (119 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPTL2	LILRB2	ENSP00000362524	ENSP00000375629	angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions	0.576
ANGPTL5	LILRB2	ENSP00000335255	ENSP00000375629	angiopoietin-like 5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions	0.576
B2M	FCGR1A	ENSP00000452780	ENSP00000358165	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	Fc fragment of IgG, high affinity Ia, receptor (CD64)	0.585
B2M	HLA-A	ENSP00000452780	ENSP00000366005	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.998
B2M	HLA-B	ENSP00000452780	ENSP00000399168	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.999
B2M	HLA-C	ENSP00000452780	ENSP00000365402	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.986
B2M	HLA-F	ENSP00000452780	ENSP00000259951	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, F	0.691
B2M	HLA-G	ENSP00000452780	ENSP00000353472	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.924
B2M	LILRB2	ENSP00000452780	ENSP00000375629	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions	0.920
FCGR1A	B2M	ENSP00000358165	ENSP00000452780	Fc fragment of IgG, high affinity Ia, receptor (CD64)	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.585
FCGR1A	LILRB2	ENSP00000358165	ENSP00000375629	Fc fragment of IgG, high affinity Ia, receptor (CD64)	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions	0.576
HLA-A	B2M	ENSP00000366005	ENSP00000452780	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.998
HLA-A	HLA-B	ENSP00000366005	ENSP00000399168	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.901
HLA-A	HLA-C	ENSP00000366005	ENSP00000365402	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-A	HLA-G	ENSP00000366005	ENSP00000353472	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.544
HLA-A	LILRB2	ENSP00000366005	ENSP00000375629	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions	0.566
HLA-B	B2M	ENSP00000399168	ENSP00000452780	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.999
HLA-B	HLA-A	ENSP00000399168	ENSP00000366005	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.901
HLA-B	HLA-C	ENSP00000399168	ENSP00000365402	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-B	HLA-G	ENSP00000399168	ENSP00000353472	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.546

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