| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC50 | EGFR | ENSP00000376250 | ENSP00000275493 | coiled-coil domain containing 50; Involved in EGFR signaling | epidermal growth factor receptor | 0.916 |
| CCDC50 | OTUD7B | ENSP00000376250 | ENSP00000358131 | coiled-coil domain containing 50; Involved in EGFR signaling | OTU domain containing 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ’Lys-11’, ’Lys-48’ or ’Lys-63’- link [...] | 0.596 |
| CCDC50 | RIPK1 | ENSP00000376250 | ENSP00000259808 | coiled-coil domain containing 50; Involved in EGFR signaling | receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at ’Ser-728’ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via ’Lys-63’-link chains acts as a critical enhancer of communication with d [...] | 0.811 |
| CCDC50 | SH3RF2 | ENSP00000376250 | ENSP00000352028 | coiled-coil domain containing 50; Involved in EGFR signaling | SH3 domain containing ring finger 2; Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function | 0.575 |
| CCDC50 | TNFAIP3 | ENSP00000376250 | ENSP00000237289 | coiled-coil domain containing 50; Involved in EGFR signaling | tumor necrosis factor, alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes i [...] | 0.576 |
| CCDC50 | UBB | ENSP00000376250 | ENSP00000304697 | coiled-coil domain containing 50; Involved in EGFR signaling | ubiquitin B | 0.574 |
| CCDC50 | UBC | ENSP00000376250 | ENSP00000344818 | coiled-coil domain containing 50; Involved in EGFR signaling | ubiquitin C | 0.998 |
| EGFR | CCDC50 | ENSP00000275493 | ENSP00000376250 | epidermal growth factor receptor | coiled-coil domain containing 50; Involved in EGFR signaling | 0.916 |
| EGFR | OTUD7B | ENSP00000275493 | ENSP00000358131 | epidermal growth factor receptor | OTU domain containing 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ’Lys-11’, ’Lys-48’ or ’Lys-63’- link [...] | 0.613 |
| EGFR | RIPK1 | ENSP00000275493 | ENSP00000259808 | epidermal growth factor receptor | receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at ’Ser-728’ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via ’Lys-63’-link chains acts as a critical enhancer of communication with d [...] | 0.622 |
| EGFR | UBB | ENSP00000275493 | ENSP00000304697 | epidermal growth factor receptor | ubiquitin B | 0.973 |
| EGFR | UBC | ENSP00000275493 | ENSP00000344818 | epidermal growth factor receptor | ubiquitin C | 0.999 |
| MYH9 | UBC | ENSP00000216181 | ENSP00000344818 | myosin, heavy chain 9, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping | ubiquitin C | 0.990 |
| OTUD7B | CCDC50 | ENSP00000358131 | ENSP00000376250 | OTU domain containing 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ’Lys-11’, ’Lys-48’ or ’Lys-63’- link [...] | coiled-coil domain containing 50; Involved in EGFR signaling | 0.596 |
| OTUD7B | EGFR | ENSP00000358131 | ENSP00000275493 | OTU domain containing 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ’Lys-11’, ’Lys-48’ or ’Lys-63’- link [...] | epidermal growth factor receptor | 0.613 |
| OTUD7B | UBB | ENSP00000358131 | ENSP00000304697 | OTU domain containing 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ’Lys-11’, ’Lys-48’ or ’Lys-63’- link [...] | ubiquitin B | 0.583 |
| OTUD7B | UBC | ENSP00000358131 | ENSP00000344818 | OTU domain containing 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ’Lys-11’, ’Lys-48’ or ’Lys-63’- link [...] | ubiquitin C | 0.993 |
| RIPK1 | CCDC50 | ENSP00000259808 | ENSP00000376250 | receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at ’Ser-728’ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via ’Lys-63’-link chains acts as a critical enhancer of communication with d [...] | coiled-coil domain containing 50; Involved in EGFR signaling | 0.811 |
| RIPK1 | EGFR | ENSP00000259808 | ENSP00000275493 | receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at ’Ser-728’ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via ’Lys-63’-link chains acts as a critical enhancer of communication with d [...] | epidermal growth factor receptor | 0.622 |
| RIPK1 | TNFAIP3 | ENSP00000259808 | ENSP00000237289 | receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at ’Ser-728’ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via ’Lys-63’-link chains acts as a critical enhancer of communication with d [...] | tumor necrosis factor, alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes i [...] | 0.996 |
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