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MYH15 MYH15 MYO3A MYO3A MYH13 MYH13 SORBS1 SORBS1 MYH10 MYH10 MYH2 MYH2 MYO5B MYO5B MYH14 MYH14 EXOC7 EXOC7 MYH7B MYH7B MYO5C MYO5C EXOC4 EXOC4 ARHGAP10 ARHGAP10 ARHGAP42 ARHGAP42 GCN1L1 GCN1L1 UBC UBC UBE2R2 UBE2R2 INF2 INF2 SORBS2 SORBS2 CD55 CD55 PFN1 PFN1 MYO1G MYO1G PFN2 PFN2 ARHGAP26 ARHGAP26 OPHN1 OPHN1 PFN4 PFN4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PFN1profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (140 aa)
PFN2profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (140 aa)
MYH2myosin, heavy chain 2, skeletal muscle, adult; Muscle contraction. Required for cytoskeleton organization (By similarity) (1941 aa)
MYH13myosin, heavy chain 13, skeletal muscle; Muscle contraction (1938 aa)
EXOC4exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (By similarity) (974 aa)
MYO1Gmyosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) (1018 aa)
MYO5Cmyosin VC; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues (1742 aa)
MYH14myosin, heavy chain 14, non-muscle (2036 aa)
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta; Involved in muscle contraction (1983 aa)
UBE2R2ubiquitin-conjugating enzyme E2R 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and ’Lys-48’-linked polyubiquitination. May be involved in degradation of katenin (238 aa)
MYO3Amyosin IIIA; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (1616 aa)
MYH10myosin, heavy chain 10, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2 (1976 aa)
MYH15myosin, heavy chain 15; Muscle contraction (By similarity) (1946 aa)
ARHGAP26Rho GTPase activating protein 26; GTPase-activating protein for RHOA and CDC42 (814 aa)
SORBS2sorbin and SH3 domain containing 2 (1100 aa)
MYO5Bmyosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity) (1848 aa)
ARHGAP42Rho GTPase activating protein 42; May act as a GTPase activator (By similarity) (874 aa)
GCN1L1GCN1 general control of amino-acid synthesis 1-like 1 (yeast) (2671 aa)
CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (440 aa)
PFN4profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) (129 aa)
EXOC7exocyst complex component 7 (735 aa)
ARHGAP10Rho GTPase activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity) (786 aa)
UBCubiquitin C (685 aa)
OPHN1oligophrenin 1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function (By similarity). Critical for the stabilization of AMPA receptors at postsynaptic sites (By similarity). Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity) (802 aa)
SORBS1sorbin and SH3 domain containing 1 (1292 aa)
INF2inverted formin, FH2 and WH2 domain containing; Severs actin filaments and accelerates their polymerization and depolymerization (By similarity) (1249 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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