node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf65 | CALM1 | ENSP00000376799 | ENSP00000349467 | chromosome 11 open reading frame 65 | calmodulin 1 (phosphorylase kinase, delta) | 0.571 |
C11orf65 | CALM2 | ENSP00000376799 | ENSP00000272298 | chromosome 11 open reading frame 65 | calmodulin 2 (phosphorylase kinase, delta) | 0.524 |
C11orf65 | CALM3 | ENSP00000376799 | ENSP00000291295 | chromosome 11 open reading frame 65 | calmodulin 3 (phosphorylase kinase, delta) | 0.537 |
C11orf65 | CALML3 | ENSP00000376799 | ENSP00000315299 | chromosome 11 open reading frame 65 | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | 0.571 |
C11orf65 | SENP2 | ENSP00000376799 | ENSP00000296257 | chromosome 11 open reading frame 65 | SUMO1/sentrin/SMT3 specific peptidase 2; Protease that catalyzes two essential functions in the SUMO pathway- processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity) | 0.475 |
CALM1 | C11orf65 | ENSP00000349467 | ENSP00000376799 | calmodulin 1 (phosphorylase kinase, delta) | chromosome 11 open reading frame 65 | 0.571 |
CALM1 | CALM2 | ENSP00000349467 | ENSP00000272298 | calmodulin 1 (phosphorylase kinase, delta) | calmodulin 2 (phosphorylase kinase, delta) | 0.901 |
CALM1 | CALM3 | ENSP00000349467 | ENSP00000291295 | calmodulin 1 (phosphorylase kinase, delta) | calmodulin 3 (phosphorylase kinase, delta) | 0.901 |
CALM2 | C11orf65 | ENSP00000272298 | ENSP00000376799 | calmodulin 2 (phosphorylase kinase, delta) | chromosome 11 open reading frame 65 | 0.524 |
CALM2 | CALM1 | ENSP00000272298 | ENSP00000349467 | calmodulin 2 (phosphorylase kinase, delta) | calmodulin 1 (phosphorylase kinase, delta) | 0.901 |
CALM2 | CALM3 | ENSP00000272298 | ENSP00000291295 | calmodulin 2 (phosphorylase kinase, delta) | calmodulin 3 (phosphorylase kinase, delta) | 0.901 |
CALM3 | C11orf65 | ENSP00000291295 | ENSP00000376799 | calmodulin 3 (phosphorylase kinase, delta) | chromosome 11 open reading frame 65 | 0.537 |
CALM3 | CALM1 | ENSP00000291295 | ENSP00000349467 | calmodulin 3 (phosphorylase kinase, delta) | calmodulin 1 (phosphorylase kinase, delta) | 0.901 |
CALM3 | CALM2 | ENSP00000291295 | ENSP00000272298 | calmodulin 3 (phosphorylase kinase, delta) | calmodulin 2 (phosphorylase kinase, delta) | 0.901 |
CALML3 | C11orf65 | ENSP00000315299 | ENSP00000376799 | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | chromosome 11 open reading frame 65 | 0.571 |
SENP2 | C11orf65 | ENSP00000296257 | ENSP00000376799 | SUMO1/sentrin/SMT3 specific peptidase 2; Protease that catalyzes two essential functions in the SUMO pathway- processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity) | chromosome 11 open reading frame 65 | 0.475 |
SENP2 | SUMO1 | ENSP00000296257 | ENSP00000376076 | SUMO1/sentrin/SMT3 specific peptidase 2; Protease that catalyzes two essential functions in the SUMO pathway- processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity) | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] | 0.999 |
SUMO1 | SENP2 | ENSP00000376076 | ENSP00000296257 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] | SUMO1/sentrin/SMT3 specific peptidase 2; Protease that catalyzes two essential functions in the SUMO pathway- processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity) | 0.999 |