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MYH1 | myosin, heavy chain 1, skeletal muscle, adult; Muscle contraction (1939 aa) | |||
MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction (1940 aa) | |||
MYH2 | myosin, heavy chain 2, skeletal muscle, adult; Muscle contraction. Required for cytoskeleton organization (By similarity) (1941 aa) | |||
MYH13 | myosin, heavy chain 13, skeletal muscle; Muscle contraction (1938 aa) | |||
MYO5C | myosin VC; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues (1742 aa) | |||
MYH14 | myosin, heavy chain 14, non-muscle (2036 aa) | |||
PI4KB | phosphatidylinositol 4-kinase, catalytic, beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (828 aa) | |||
MYO5B | myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity) (1848 aa) | |||
CCDC34 | coiled-coil domain containing 34 (373 aa) | |||
MYO18B | myosin XVIIIB (2567 aa) | |||
MYH7 | myosin, heavy chain 7, cardiac muscle, beta (1935 aa) | |||
RAB11FIP2 | RAB11 family interacting protein 2 (class I); A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity (512 aa) | |||
MYH6 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction (1939 aa) | |||
SPTBN1 | spectrin, beta, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane (2364 aa) | |||
TBC1D9B | TBC1 domain family, member 9B (with GRAM domain); May act as a GTPase-activating protein for Rab family protein(s) (1250 aa) | |||
SMC5 | structural maintenance of chromosomes 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). R [...] (1101 aa) | |||
SLK | STE20-like kinase (1235 aa) | |||
SPTAN1 | spectrin, alpha, non-erythrocytic 1 (2477 aa) | |||
GDI2 | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (445 aa) | |||
RABL2A | RAB, member of RAS oncogene family-like 2A (228 aa) | |||
RAB3IL1 | RAB3A interacting protein (rabin3)-like 1; Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B (382 aa) | |||
MYH11 | myosin, heavy chain 11, smooth muscle; Muscle contraction (1979 aa) | |||
MYO5A | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (1855 aa) | |||
GDI1 | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (447 aa) | |||
RAB3IP | RAB3A interacting protein (rabin3) (476 aa) | |||
ENSG00000258052 | Uncharacterized protein (76 aa) |