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ENSG00000268500 ENSG00000268500 EGFLAM EGFLAM SIGLEC6 SIGLEC6 SIGLEC8 SIGLEC8 BTN3A3 BTN3A3 SIGLEC12 SIGLEC12 BTN2A2 BTN2A2 HSPG2 HSPG2 SIGLEC10 SIGLEC10 BTNL9 BTNL9 CD33 CD33 HDAC1 HDAC1 TAPBPL TAPBPL BTN1A1 BTN1A1 PVRL4 PVRL4 BTN2A1 BTN2A1 CTLA4 CTLA4 IGSF11 IGSF11 BTNL2 BTNL2 BTN3A1 BTN3A1 SIGLEC7 SIGLEC7 CD28 CD28 SIGLEC14 SIGLEC14 SIGLEC11 SIGLEC11 EYS EYS SIGLEC9 SIGLEC9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
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protein homology
Your Input:
BTN1A1butyrophilin, subfamily 1, member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity) (526 aa)
BTN3A3butyrophilin, subfamily 3, member A3; Plays a role in T-cell responses in the adaptive immune response (584 aa)
CD33CD33 molecule; Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro) (364 aa)
TAPBPLTAP binding protein-like (468 aa)
BTN3A1butyrophilin, subfamily 3, member A1 (513 aa)
SIGLEC12sialic acid binding Ig-like lectin 12 (gene/pseudogene); Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (595 aa)
CTLA4cytotoxic T-lymphocyte-associated protein 4 (223 aa)
BTN2A1butyrophilin, subfamily 2, member A1 (527 aa)
SIGLEC8sialic acid binding Ig-like lectin 8; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (499 aa)
SIGLEC7sialic acid binding Ig-like lectin 7; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their [...] (467 aa)
CD28CD28 molecule (220 aa)
BTNL9butyrophilin-like 9 (535 aa)
SIGLEC10sialic acid binding Ig-like lectin 10 (697 aa)
EGFLAMEGF-like, fibronectin type III and laminin G domains (1017 aa)
BTN2A2butyrophilin, subfamily 2, member A2; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity) (523 aa)
SIGLEC14sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors (396 aa)
PVRL4poliovirus receptor-related 4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells (510 aa)
HDAC1histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] (482 aa)
HSPG2heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (4391 aa)
IGSF11immunoglobulin superfamily, member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (431 aa)
SIGLEC6sialic acid binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (453 aa)
SIGLEC11sialic acid binding Ig-like lectin 11; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (698 aa)
SIGLEC9sialic acid binding Ig-like lectin 9; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (479 aa)
ENSG00000268500Sialic acid-binding Ig-like lectin 5 ; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (551 aa)
BTNL2butyrophilin-like 2 (MHC class II associated) (482 aa)
EYSeyes shut homolog (Drosophila) (3144 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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