node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCG2 | UBC | ENSP00000237612 | ENSP00000344818 | ATP-binding cassette, sub-family G (WHITE), member 2 | ubiquitin C | 0.724 |
CDC25B | UBC | ENSP00000245960 | ENSP00000344818 | cell division cycle 25 homolog B (S. pombe) | ubiquitin C | 0.864 |
DLG3 | UBC | ENSP00000363480 | ENSP00000344818 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | ubiquitin C | 0.759 |
EPS15 | GRB2 | ENSP00000360798 | ENSP00000339007 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.998 |
EPS15 | UBC | ENSP00000360798 | ENSP00000344818 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | ubiquitin C | 0.999 |
GRB2 | EPS15 | ENSP00000339007 | ENSP00000360798 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | 0.998 |
GRB2 | UBC | ENSP00000339007 | ENSP00000344818 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | ubiquitin C | 0.949 |
KRT35 | RAB24 | ENSP00000377558 | ENSP00000304376 | keratin 35 | RAB24, member RAS oncogene family; May be involved in autophagy-related processes (By similarity) | 0.456 |
KRT35 | USP15 | ENSP00000377558 | ENSP00000258123 | keratin 35 | ubiquitin specific peptidase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear- according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed-21947082). According to another reports, regulates the TGF-beta receptor s [...] | 0.740 |
RAB24 | KRT35 | ENSP00000304376 | ENSP00000377558 | RAB24, member RAS oncogene family; May be involved in autophagy-related processes (By similarity) | keratin 35 | 0.456 |
RAB24 | UBC | ENSP00000304376 | ENSP00000344818 | RAB24, member RAS oncogene family; May be involved in autophagy-related processes (By similarity) | ubiquitin C | 0.663 |
UBC | ABCG2 | ENSP00000344818 | ENSP00000237612 | ubiquitin C | ATP-binding cassette, sub-family G (WHITE), member 2 | 0.724 |
UBC | CDC25B | ENSP00000344818 | ENSP00000245960 | ubiquitin C | cell division cycle 25 homolog B (S. pombe) | 0.864 |
UBC | DLG3 | ENSP00000344818 | ENSP00000363480 | ubiquitin C | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | 0.759 |
UBC | EPS15 | ENSP00000344818 | ENSP00000360798 | ubiquitin C | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | 0.999 |
UBC | GRB2 | ENSP00000344818 | ENSP00000339007 | ubiquitin C | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.949 |
UBC | RAB24 | ENSP00000344818 | ENSP00000304376 | ubiquitin C | RAB24, member RAS oncogene family; May be involved in autophagy-related processes (By similarity) | 0.663 |
UBC | USP15 | ENSP00000344818 | ENSP00000258123 | ubiquitin C | ubiquitin specific peptidase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear- according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed-21947082). According to another reports, regulates the TGF-beta receptor s [...] | 0.999 |
USP15 | KRT35 | ENSP00000258123 | ENSP00000377558 | ubiquitin specific peptidase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear- according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed-21947082). According to another reports, regulates the TGF-beta receptor s [...] | keratin 35 | 0.740 |
USP15 | UBC | ENSP00000258123 | ENSP00000344818 | ubiquitin specific peptidase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear- according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed-21947082). According to another reports, regulates the TGF-beta receptor s [...] | ubiquitin C | 0.999 |