node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL1 | SCOC | ENSP00000261636 | ENSP00000377751 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | short coiled-coil protein | 0.588 |
ARL1 | UBC | ENSP00000261636 | ENSP00000344818 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | ubiquitin C | 0.725 |
EPB41L3 | UBC | ENSP00000341138 | ENSP00000344818 | erythrocyte membrane protein band 4.1-like 3; Critical growth regulator in the pathogenesis of meningiomas | ubiquitin C | 0.621 |
FEZ1 | FEZ2 | ENSP00000278919 | ENSP00000368547 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | 0.486 |
FEZ1 | SCOC | ENSP00000278919 | ENSP00000377751 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | short coiled-coil protein | 0.988 |
FEZ1 | UBC | ENSP00000278919 | ENSP00000344818 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | ubiquitin C | 0.576 |
FEZ2 | FEZ1 | ENSP00000368547 | ENSP00000278919 | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | 0.486 |
FEZ2 | SCOC | ENSP00000368547 | ENSP00000377751 | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | short coiled-coil protein | 0.927 |
FEZ2 | UBC | ENSP00000368547 | ENSP00000344818 | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | ubiquitin C | 0.483 |
ITSN1 | UBC | ENSP00000370719 | ENSP00000344818 | intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 | ubiquitin C | 0.738 |
MAP1LC3B | SCOC | ENSP00000268607 | ENSP00000377751 | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | short coiled-coil protein | 0.575 |
MAP1LC3B | UBC | ENSP00000268607 | ENSP00000344818 | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | ubiquitin C | 0.545 |
MAPK8 | UBC | ENSP00000353483 | ENSP00000344818 | mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JU [...] | ubiquitin C | 0.657 |
SCOC | ARL1 | ENSP00000377751 | ENSP00000261636 | short coiled-coil protein | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | 0.588 |
SCOC | FEZ1 | ENSP00000377751 | ENSP00000278919 | short coiled-coil protein | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | 0.988 |
SCOC | FEZ2 | ENSP00000377751 | ENSP00000368547 | short coiled-coil protein | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | 0.927 |
SCOC | MAP1LC3B | ENSP00000377751 | ENSP00000268607 | short coiled-coil protein | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.575 |
SCOC | TGOLN2 | ENSP00000377751 | ENSP00000386443 | short coiled-coil protein | trans-golgi network protein 2 | 0.589 |
TCF4 | UBC | ENSP00000346440 | ENSP00000344818 | transcription factor 4 | ubiquitin C | 0.955 |
TGOLN2 | SCOC | ENSP00000386443 | ENSP00000377751 | trans-golgi network protein 2 | short coiled-coil protein | 0.589 |