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RELT | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation (430 aa) | |||
CADM4 | cell adhesion molecule 4; Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity (388 aa) | |||
PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma); Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1 (461 aa) | |||
TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis (440 aa) | |||
RNF149 | ring finger protein 149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation (400 aa) | |||
PTPRF | protein tyrosine phosphatase, receptor type, F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (1907 aa) | |||
UGCG | UDP-glucose ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase" (394 aa) | |||
HEPACAM2 | HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes- anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation (462 aa) |