Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | TFPI2 | tissue factor pathway inhibitor 2; May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin (235 aa) | ||
 | PTK7 | PTK7 protein tyrosine kinase 7 (1070 aa) | ||
 | C3 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (1663 aa) | ||
 | TECTA | tectorin alpha; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals (2155 aa) | ||
 | FRAS1 | Fraser syndrome 1 (4012 aa) | ||
 | SPINT4 | serine peptidase inhibitor, Kunitz type 4 (99 aa) | ||
 | C2 | complement component 2 (752 aa) | ||
 | CD46 | CD46 molecule, complement regulatory protein (399 aa) | ||
 | ENSG00000179066 | Uncharacterized protein (148 aa) | ||
 | VWCE | von Willebrand factor C and EGF domains; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma (955 aa) | ||
 | CR1 | complement component (3b/4b) receptor 1 (Knops blood group); Mediates cellular binding of particles and immune complexes that have activated complement (2489 aa) | ||
 | CFHR3 | complement factor H-related 3; Might be involved in complement regulation (330 aa) | ||
 | CFH | complement factor H (1231 aa) | ||
 | ECM1 | extracellular matrix protein 1 (567 aa) | ||
 | CFI | complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively (583 aa) | ||
 | C4A | complement component 4A (Rodgers blood group) (1744 aa) | ||
 | OTOGL | otogelin-like (2344 aa) | ||
 | MUC6 | mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis (2439 aa) | ||
 | MUC2 | mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer (2817 aa) | ||
 | C4B | complement component 4B (Chido blood group) (1744 aa) | ||
 | CFB | complement factor B (764 aa) | ||
 | TENM2 | teneurin transmembrane protein 2; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer (2774 aa) | ||
 | MUC5AC | mucin 5AC, oligomeric mucus/gel-forming (623 aa) | ||
 | MUC5B | mucin 5B, oligomeric mucus/gel-forming (5762 aa) | ||
 | EPPIN | epididymal peptidase inhibitor; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (179 aa) | ||
 | ENSG00000267748 | Protein C19orf33 (158 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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