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SETDB1 SETDB1 CACNG6 CACNG6 CACNB4 CACNB4 CACNG2 CACNG2 CACNA1H CACNA1H CACNA2D1 CACNA2D1 CACNB3 CACNB3 CACNG7 CACNG7 CATSPER4 CATSPER4 PRKACA PRKACA CACNG3 CACNG3 CACNA1D CACNA1D CACNA1E CACNA1E CACNA1S CACNA1S CACNG8 CACNG8 CACNA1F CACNA1F CACNA1C CACNA1C TRPC4 TRPC4 CACNA2D4 CACNA2D4 PKD1L1 PKD1L1 TRPC5 TRPC5 PKD2L1 PKD2L1 EFHA1 EFHA1 MICU1 MICU1 C22orf32 C22orf32 CCDC109B CCDC109B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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from curated databases
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experimentally determined
Predicted Interactions
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textmining
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co-expression
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CACNG3calcium channel, voltage-dependent, gamma subunit 3; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity) (315 aa)
CACNG7calcium channel, voltage-dependent, gamma subunit 7; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (275 aa)
CACNG6calcium channel, voltage-dependent, gamma subunit 6; Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity) (260 aa)
TRPC5transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion (973 aa)
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit (2186 aa)
CACNG8calcium channel, voltage-dependent, gamma subunit 8; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (425 aa)
SETDB1SET domain, bifurcated 1; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 ’Lys-9’ trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ’Lys-9’ trimethylation. It [...] (1291 aa)
CACNA1Dcalcium channel, voltage-dependent, L type, alpha 1D subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] (2181 aa)
PKD1L1polycystic kidney disease 1 like 1; May have a role in the heart and in the male reproductive system (2849 aa)
CACNG2calcium channel, voltage-dependent, gamma subunit 2; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (323 aa)
CACNB3calcium channel, voltage-dependent, beta 3 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting (484 aa)
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] (351 aa)
PKD2L1polycystic kidney disease 2-like 1; May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling (805 aa)
C22orf32chromosome 22 open reading frame 32 (107 aa)
CACNA1Hcalcium channel, voltage-dependent, T type, alpha 1H subunit (2353 aa)
CACNA2D1calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) (1091 aa)
MICU1mitochondrial calcium uptake 1 (476 aa)
CACNA1Scalcium channel, voltage-dependent, L type, alpha 1S subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] (1873 aa)
CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however ins [...] (2313 aa)
CACNA1Fcalcium channel, voltage-dependent, L type, alpha 1F subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] (1977 aa)
TRPC4transient receptor potential cation channel, subfamily C, member 4 (982 aa)
EFHA1EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) (434 aa)
CACNA2D4calcium channel, voltage-dependent, alpha 2/delta subunit 4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (1137 aa)
CCDC109Bcoiled-coil domain containing 109B (336 aa)
CATSPER4cation channel, sperm associated 4; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] (472 aa)
CACNB4calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting (520 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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