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PIGA PIGA MAOB MAOB PARP4 PARP4 ALG1L ALG1L ALG2 ALG2 CDC40 CDC40 CGRRF1 CGRRF1 DPAGT1 DPAGT1 ALG11 ALG11 SAV1 SAV1 ALG13 ALG13 ALG1 ALG1 ALG14 ALG14 UBR2 UBR2 GYS2 GYS2 GYS1 GYS1 UBR1 UBR1 KDM1B KDM1B PITX1 PITX1 GANC GANC RBFOX1 RBFOX1 MAOA MAOA RERE RERE KDM1A KDM1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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CGRRF1cell growth regulator with ring finger domain 1; Able to inhibit growth in several cell lines (By similarity) (332 aa)
GYS2glycogen synthase 2 (liver); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan (703 aa)
ALG1asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae); Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (464 aa)
PITX1paired-like homeodomain 1; May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb (314 aa)
UBR1ubiquitin protein ligase E3 component n-recognin 1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (1749 aa)
KDM1Blysine (K)-specific demethylase 1B; Histone demethylase that demethylates ’Lys-4’ of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated ’Lys-4’ of histone H3. Has no effect on tri- methylated ’Lys-4’, mono-, di- or tri-methylated ’Lys-9’, mono-, di- or tri-methylated ’Lys-27’, mono-, di- or tri-methylat [...] (590 aa)
CDC40cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing (579 aa)
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 1; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (418 aa)
GYS1glycogen synthase 1 (muscle); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan (737 aa)
SAV1salvador homolog 1 (Drosophila); Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the n [...] (383 aa)
GANCglucosidase, alpha; neutral C; Has alpha-glucosidase activity (914 aa)
REREarginine-glutamic acid dipeptide (RE) repeats; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death (1566 aa)
ALG1Lasparagine-linked glycosylation 1-like; Putative glycosyltransferase (By similarity) (187 aa)
MAOAmonoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (527 aa)
DPAGT1dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase); Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides (408 aa)
ALG14asparagine-linked glycosylation 14 homolog (S. cerevisiae); May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER (216 aa)
UBR2ubiquitin protein ligase E3 component n-recognin 2; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (1755 aa)
MAOBmonoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (520 aa)
PIGAphosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis (484 aa)
PARP4poly (ADP-ribose) polymerase family, member 4 (1724 aa)
ALG13asparagine-linked glycosylation 13 homolog (S. cerevisiae) (1137 aa)
KDM1Alysine (K)-specific demethylase 1A (876 aa)
ALG2asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae); Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate (416 aa)
ALG11asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast); Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol- linked oligosaccharide chain (492 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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