node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLDN1 | CLDN3 | ENSP00000295522 | ENSP00000378577 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | claudin 3 | 0.576 |
CLDN1 | CLDN5 | ENSP00000295522 | ENSP00000384554 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.914 |
CLDN1 | TJP1 | ENSP00000295522 | ENSP00000281537 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.979 |
CLDN1 | WNK4 | ENSP00000295522 | ENSP00000246914 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.620 |
CLDN3 | CLDN1 | ENSP00000378577 | ENSP00000295522 | claudin 3 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | 0.576 |
CLDN3 | CLDN5 | ENSP00000378577 | ENSP00000384554 | claudin 3 | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.564 |
CLDN3 | PRKACA | ENSP00000378577 | ENSP00000309591 | claudin 3 | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | 0.576 |
CLDN3 | TJP1 | ENSP00000378577 | ENSP00000281537 | claudin 3 | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.597 |
CLDN3 | WNK4 | ENSP00000378577 | ENSP00000246914 | claudin 3 | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.564 |
CLDN5 | CLDN1 | ENSP00000384554 | ENSP00000295522 | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | 0.914 |
CLDN5 | CLDN3 | ENSP00000384554 | ENSP00000378577 | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | claudin 3 | 0.564 |
CLDN5 | TJP1 | ENSP00000384554 | ENSP00000281537 | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.983 |
PRKACA | CLDN3 | ENSP00000309591 | ENSP00000378577 | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | claudin 3 | 0.576 |
TJP1 | CLDN1 | ENSP00000281537 | ENSP00000295522 | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | 0.979 |
TJP1 | CLDN3 | ENSP00000281537 | ENSP00000378577 | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | claudin 3 | 0.597 |
TJP1 | CLDN5 | ENSP00000281537 | ENSP00000384554 | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.983 |
WNK4 | CLDN1 | ENSP00000246914 | ENSP00000295522 | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | 0.620 |
WNK4 | CLDN3 | ENSP00000246914 | ENSP00000378577 | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | claudin 3 | 0.564 |