node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRMP1 | DPYSL2 | ENSP00000321606 | ENSP00000309539 | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | 0.987 |
CRMP1 | DPYSL4 | ENSP00000321606 | ENSP00000339850 | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | dihydropyrimidinase-like 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | 0.909 |
DAG1 | DRP2 | ENSP00000312435 | ENSP00000378635 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | 0.648 |
DAG1 | PRX | ENSP00000312435 | ENSP00000326018 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | periaxin; Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition | 0.614 |
DAG1 | UTRN | ENSP00000312435 | ENSP00000356515 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) | 0.999 |
DISC1 | DPYSL2 | ENSP00000355593 | ENSP00000309539 | disrupted in schizophrenia 1 | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | 0.898 |
DPYSL2 | CRMP1 | ENSP00000309539 | ENSP00000321606 | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | 0.987 |
DPYSL2 | DISC1 | ENSP00000309539 | ENSP00000355593 | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | disrupted in schizophrenia 1 | 0.898 |
DPYSL2 | DPYSL4 | ENSP00000309539 | ENSP00000339850 | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | dihydropyrimidinase-like 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | 0.919 |
DPYSL2 | DRP2 | ENSP00000309539 | ENSP00000378635 | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | 0.603 |
DPYSL4 | CRMP1 | ENSP00000339850 | ENSP00000321606 | dihydropyrimidinase-like 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | 0.909 |
DPYSL4 | DPYSL2 | ENSP00000339850 | ENSP00000309539 | dihydropyrimidinase-like 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | 0.919 |
DRP2 | DAG1 | ENSP00000378635 | ENSP00000312435 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.648 |
DRP2 | DPYSL2 | ENSP00000378635 | ENSP00000309539 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | 0.603 |
DRP2 | DTNA | ENSP00000378635 | ENSP00000382064 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | dystrobrevin, alpha | 0.628 |
DRP2 | PRX | ENSP00000378635 | ENSP00000326018 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | periaxin; Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition | 0.782 |
DRP2 | UTRN | ENSP00000378635 | ENSP00000356515 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) | 0.583 |
DTNA | DRP2 | ENSP00000382064 | ENSP00000378635 | dystrobrevin, alpha | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | 0.628 |
DTNA | UTRN | ENSP00000382064 | ENSP00000356515 | dystrobrevin, alpha | utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) | 0.946 |
PPP1CA | PPP1CC | ENSP00000326031 | ENSP00000335084 | protein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] | protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca [...] | 0.960 |