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STRINGSTRING
HSPA8 HSPA8 HLA-DQB2 HLA-DQB2 YWHAE YWHAE PKM PKM HSP90AA1 HSP90AA1 HSP90AB1 HSP90AB1 ATP1B1 ATP1B1 MS4A1 MS4A1 MARCH1 MARCH1 UBC UBC ANXA11 ANXA11 CD63 CD63 PRPF40B PRPF40B HLA-DRA HLA-DRA HLA-DRB5 HLA-DRB5 CD82 CD82 HLA-C HLA-C HLA-DQB1 HLA-DQB1 CD74 CD74 HLA-DMA HLA-DMA HLA-DRB1 HLA-DRB1 MBP MBP HLA-DPB1 HLA-DPB1 HLA-DOB HLA-DOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CD74CD74 molecule, major histocompatibility complex, class II invariant chain (296 aa)
CD82CD82 molecule; Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway (267 aa)
HSPA8heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (646 aa)
CD63CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation (238 aa)
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (255 aa)
ANXA11annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis (505 aa)
MARCH1membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system (289 aa)
MS4A1membrane-spanning 4-domains, subfamily A, member 1; This protein may be involved in the regulation of B-cell activation and proliferation (297 aa)
PKMpyruvate kinase, muscle (531 aa)
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (724 aa)
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (854 aa)
UBCubiquitin C (685 aa)
HLA-DRB1major histocompatibility complex, class II, DR beta 1 (266 aa)
ATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (303 aa)
HLA-DMAmajor histocompatibility complex, class II, DM alpha (261 aa)
HLA-DRB5major histocompatibility complex, class II, DR beta 5 (266 aa)
HLA-Cmajor histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) (366 aa)
PRPF40BPRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae); May be involved in pre-mRNA splicing (871 aa)
MBPmyelin basic protein (197 aa)
HLA-DRAmajor histocompatibility complex, class II, DR alpha (254 aa)
HLA-DQB1major histocompatibility complex, class II, DQ beta 1 (261 aa)
HLA-DOBmajor histocompatibility complex, class II, DO beta (273 aa)
HLA-DQB2major histocompatibility complex, class II, DQ beta 2 (227 aa)
HLA-DPB1major histocompatibility complex, class II, DP beta 1 (258 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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