node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNM1L | SMCR7 | ENSP00000450399 | ENSP00000379057 | dynamin 1-like | Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface | 0.872 |
DNM1L | TOMM20 | ENSP00000450399 | ENSP00000355566 | dynamin 1-like | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | 0.601 |
DNM1L | UBC | ENSP00000450399 | ENSP00000344818 | dynamin 1-like | ubiquitin C | 0.989 |
RABAC1 | SMCR7 | ENSP00000222008 | ENSP00000379057 | Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity) | Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface | 0.465 |
RABAC1 | UBC | ENSP00000222008 | ENSP00000344818 | Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity) | ubiquitin C | 0.963 |
SMCR7 | DNM1L | ENSP00000379057 | ENSP00000450399 | Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface | dynamin 1-like | 0.872 |
SMCR7 | RABAC1 | ENSP00000379057 | ENSP00000222008 | Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface | Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity) | 0.465 |
SMCR7 | TOMM20 | ENSP00000379057 | ENSP00000355566 | Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | 0.576 |
SMCR7 | UBC | ENSP00000379057 | ENSP00000344818 | Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface | ubiquitin C | 0.620 |
TOMM20 | DNM1L | ENSP00000355566 | ENSP00000450399 | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | dynamin 1-like | 0.601 |
TOMM20 | SMCR7 | ENSP00000355566 | ENSP00000379057 | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface | 0.576 |
TOMM20 | UBC | ENSP00000355566 | ENSP00000344818 | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | ubiquitin C | 0.823 |
UBC | DNM1L | ENSP00000344818 | ENSP00000450399 | ubiquitin C | dynamin 1-like | 0.989 |
UBC | RABAC1 | ENSP00000344818 | ENSP00000222008 | ubiquitin C | Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity) | 0.963 |
UBC | SMCR7 | ENSP00000344818 | ENSP00000379057 | ubiquitin C | Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface | 0.620 |
UBC | TOMM20 | ENSP00000344818 | ENSP00000355566 | ubiquitin C | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | 0.823 |
UBC | UBQLN1 | ENSP00000344818 | ENSP00000365576 | ubiquitin C | ubiquilin 1; Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation | 0.999 |
UBC | UBQLN4 | ENSP00000344818 | ENSP00000357292 | ubiquitin C | ubiquilin 4; Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation | 0.991 |
UBQLN1 | UBC | ENSP00000365576 | ENSP00000344818 | ubiquilin 1; Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation | ubiquitin C | 0.999 |
UBQLN1 | UBQLN4 | ENSP00000365576 | ENSP00000357292 | ubiquilin 1; Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation | ubiquilin 4; Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation | 0.963 |