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JUND | jun D proto-oncogene; Transcription factor binding AP-1 sites (347 aa) | |||
WDR90 | WD repeat domain 90 (1748 aa) | |||
JUNB | jun B proto-oncogene; Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5’-TGA[CG]TCA-3’ (347 aa) | |||
BOLA2B | bolA homolog 2B (E. coli) (152 aa) | |||
RNF4 | ring finger protein 4; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates ’Lys-6’-, ’Lys-11’-, ’Lys-48’- and ’Lys-63’-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses t [...] (190 aa) | |||
WSB2 | WD repeat and SOCS box containing 2; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (404 aa) | |||
UBE2I | ubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) (158 aa) | |||
GLRX5 | glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (157 aa) | |||
WDR5B | WD repeat domain 5B; May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex (By similarity) (330 aa) | |||
GLRX3 | glutaredoxin 3; Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (335 aa) | |||
BOLA2 | bolA homolog 2 (E. coli) (152 aa) | |||
SNURF | SNRPN upstream reading frame (71 aa) | |||
RRP1B | ribosomal RNA processing 1 homolog B (S. cerevisiae) (758 aa) | |||
WDR16 | WD repeat domain 16; May play an essential role in the growth or survival of hepatocellular carcinoma (HCC) (620 aa) | |||
NFYA | nuclear transcription factor Y, alpha; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes (347 aa) | |||
WDR88 | WD repeat domain 88 (472 aa) | |||
WDR5 | WD repeat domain 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at ’Lys-4’. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (334 aa) | |||
JUN | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (331 aa) | |||
WDR38 | WD repeat domain 38 (314 aa) | |||
SUMO1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] (101 aa) | |||
ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila); Histone methyltransferase specifically methylating ’Lys- 36’ of histone H3 (H3K36me) (2964 aa) | |||
PBRM1 | polybromo 1 (1582 aa) | |||
TRPS1 | trichorhinophalangeal syndrome I; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes (1294 aa) | |||
NLK | nemo-like kinase; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis [...] (527 aa) | |||
RRP1 | ribosomal RNA processing 1 homolog (S. cerevisiae); Plays a critical role in the generation of 28S rRNA (461 aa) | |||
ENSG00000259371 | Uncharacterized protein (276 aa) |