node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAT2 | NAV2 | ENSP00000237283 | ENSP00000379394 | adenosine deaminase, tRNA-specific 2; Probably participates in deamination of adenosine-34 to inosine in many tRNAs (By similarity) | neuron navigator 2 | 0.571 |
APC | MAPRE1 | ENSP00000257430 | ENSP00000364721 | adenomatous polyposis coli; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of M [...] | microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration | 0.975 |
CCDC147 | NAV2 | ENSP00000358718 | ENSP00000379394 | coiled-coil domain containing 147 | neuron navigator 2 | 0.571 |
ING4 | MORF4L1 | ENSP00000380024 | ENSP00000331310 | inhibitor of growth family, member 4 | mortality factor 4 like 1 | 0.828 |
ING4 | NAV2 | ENSP00000380024 | ENSP00000379394 | inhibitor of growth family, member 4 | neuron navigator 2 | 0.587 |
ING5 | MORF4L1 | ENSP00000322142 | ENSP00000331310 | inhibitor of growth family, member 5; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator | mortality factor 4 like 1 | 0.828 |
ING5 | NAV2 | ENSP00000322142 | ENSP00000379394 | inhibitor of growth family, member 5; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator | neuron navigator 2 | 0.546 |
MAPRE1 | APC | ENSP00000364721 | ENSP00000257430 | microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration | adenomatous polyposis coli; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of M [...] | 0.975 |
MAPRE1 | NAV2 | ENSP00000364721 | ENSP00000379394 | microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration | neuron navigator 2 | 0.570 |
MAPRE1 | TRIO | ENSP00000364721 | ENSP00000339299 | microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration | trio Rho guanine nucleotide exchange factor; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth | 0.570 |
MORF4L1 | ING4 | ENSP00000331310 | ENSP00000380024 | mortality factor 4 like 1 | inhibitor of growth family, member 4 | 0.828 |
MORF4L1 | ING5 | ENSP00000331310 | ENSP00000322142 | mortality factor 4 like 1 | inhibitor of growth family, member 5; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator | 0.828 |
NAV2 | ADAT2 | ENSP00000379394 | ENSP00000237283 | neuron navigator 2 | adenosine deaminase, tRNA-specific 2; Probably participates in deamination of adenosine-34 to inosine in many tRNAs (By similarity) | 0.571 |
NAV2 | CCDC147 | ENSP00000379394 | ENSP00000358718 | neuron navigator 2 | coiled-coil domain containing 147 | 0.571 |
NAV2 | ING4 | ENSP00000379394 | ENSP00000380024 | neuron navigator 2 | inhibitor of growth family, member 4 | 0.587 |
NAV2 | ING5 | ENSP00000379394 | ENSP00000322142 | neuron navigator 2 | inhibitor of growth family, member 5; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator | 0.546 |
NAV2 | MAPRE1 | ENSP00000379394 | ENSP00000364721 | neuron navigator 2 | microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration | 0.570 |
NAV2 | PIAS2 | ENSP00000379394 | ENSP00000465676 | neuron navigator 2 | protein inhibitor of activated STAT, 2; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Bin [...] | 0.623 |
NAV2 | RRAS | ENSP00000379394 | ENSP00000246792 | neuron navigator 2 | related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton | 0.572 |
NAV2 | TRIO | ENSP00000379394 | ENSP00000339299 | neuron navigator 2 | trio Rho guanine nucleotide exchange factor; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth | 0.610 |