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HFM1 HFM1 DNAJC15 DNAJC15 FAF2 FAF2 CRN7 CRN7 PAM16 PAM16 TIMM23B TIMM23B TIMM44 TIMM44 PMPCA PMPCA HSPA9 HSPA9 UQCRC1 UQCRC1 TIMM50 TIMM50 OXA1L OXA1L TIMM17A TIMM17A PMPCB PMPCB TIMM17B TIMM17B MRPL23 MRPL23 TIMM23 TIMM23 COX5B COX5B MRPL32 MRPL32 DNAJC19 DNAJC19 UQCRC2 UQCRC2 FAM82A2 FAM82A2 SRSF5 SRSF5 LY6E LY6E SNRNP200 SNRNP200 ASCC3 ASCC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
UQCRC1ubiquinol-cytochrome c reductase core protein I; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (480 aa)
MRPL32mitochondrial ribosomal protein L32 (188 aa)
PMPCBpeptidase (mitochondrial processing) beta; Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity) (489 aa)
COX5Bcytochrome c oxidase subunit Vb; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (129 aa)
FAM82A2family with sequence similarity 82, member A2; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (470 aa)
TIMM23translocase of inner mitochondrial membrane 23 homolog (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (209 aa)
FAF2Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (445 aa)
UQCRC2ubiquinol-cytochrome c reductase core protein II; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex (453 aa)
TIMM44translocase of inner mitochondrial membrane 44 homolog (yeast); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (452 aa)
OXA1Loxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria (495 aa)
LY6Elymphocyte antigen 6 complex, locus E (131 aa)
HSPA9heat shock 70kDa protein 9 (mortalin) (679 aa)
PAM16presequence translocase-associated motor 16 homolog (S. cerevisiae); Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity (125 aa)
SNRNP200small nuclear ribonucleoprotein 200kDa (U5); RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (2136 aa)
TIMM50translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body (456 aa)
TIMM17Atranslocase of inner mitochondrial membrane 17 homolog A (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (171 aa)
ASCC3activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation (2202 aa)
HFM1HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) (1435 aa)
PMPCApeptidase (mitochondrial processing) alpha; Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity) (525 aa)
TIMM23Btranslocase of inner mitochondrial membrane 23 homolog B (yeast); May participate in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity) (171 aa)
DNAJC15DnaJ (Hsp40) homolog, subfamily C, member 15 (150 aa)
MRPL23mitochondrial ribosomal protein L23 (153 aa)
DNAJC19DnaJ (Hsp40) homolog, subfamily C, member 19; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity) (116 aa)
SRSF5serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (272 aa)
TIMM17Btranslocase of inner mitochondrial membrane 17 homolog B (yeast) (222 aa)
CRN7CORO7-PAM16 readthrough; May play a role in the maintenance of the Golgi apparatus morphology and in the protein export from the Golgi (1048 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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