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ZNF238 ZNF238 KRTAP10-5 KRTAP10-5 KRTAP10-1 KRTAP10-1 RRM2B RRM2B TNNT3 TNNT3 CLIP4 CLIP4 MYBPC2 MYBPC2 TNNT1 TNNT1 RRM2 RRM2 DST DST ACTN2 ACTN2 MYH3 MYH3 UBC UBC GLI3 GLI3 ZNF160 ZNF160 PDE4DIP PDE4DIP ZIC2 ZIC2 GLI1 GLI1 SIRT1 SIRT1 GLI2 GLI2 ROPN1 ROPN1 TULP3 TULP3 TBC1D5 TBC1D5 PSTPIP1 PSTPIP1 ANKRD1 ANKRD1 ANKRD54 ANKRD54
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ROPN1rhophilin associated tail protein 1 (212 aa)
SIRT1sirtuin 1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Se [...] (747 aa)
ANKRD54ankyrin repeat domain 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation (By similarity) (300 aa)
MYH3myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction (1940 aa)
GLI1GLI family zinc finger 1; Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation (1106 aa)
DSTdystonin (5171 aa)
RRM2Bribonucleotide reductase M2 B (TP53 inducible) (351 aa)
TNNT3troponin T type 3 (skeletal, fast) (258 aa)
CLIP4CAP-GLY domain containing linker protein family, member 4 (705 aa)
UBCubiquitin C (685 aa)
MYBPC2myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (1141 aa)
ZNF238zinc finger protein 238; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons (By similarity). Specifically binds the consensus DNA sequence 5’- [AC]ACATCTG[GT][AC]-3’ which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also pla [...] (531 aa)
RRM2ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (449 aa)
GLI2GLI family zinc finger 2; Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5’-GAACCACCCA-3’ which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Is involved in the smoothened (SHH) signaling pathway (1586 aa)
ACTN2actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (894 aa)
PDE4DIPphosphodiesterase 4D interacting protein (2362 aa)
ANKRD1ankyrin repeat domain 1 (cardiac muscle); May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells (319 aa)
ZIC2Zic family member 2; Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5’-TGGGTG [...] (532 aa)
GLI3GLI family zinc finger 3; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulatin [...] (1580 aa)
TULP3tubby like protein 3; Negative regulator of the Shh signaling transduction pathway- recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis (501 aa)
KRTAP10-5keratin associated protein 10-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (271 aa)
KRTAP10-1keratin associated protein 10-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (282 aa)
TBC1D5TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s) (817 aa)
ZNF160zinc finger protein 160; May be involved in transcriptional regulation (818 aa)
PSTPIP1proline-serine-threonine phosphatase interacting protein 1; Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell-APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By simi [...] (416 aa)
TNNT1troponin T type 1 (skeletal, slow); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (278 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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