node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL6 | YY1 | ENSP00000232014 | ENSP00000262238 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | YY1 transcription factor; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repre [...] | 0.456 |
GLI2 | GLI3 | ENSP00000354586 | ENSP00000379258 | GLI family zinc finger 2; Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5’-GAACCACCCA-3’ which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Is involved in the smoothened (SHH) signaling pathway | GLI family zinc finger 3; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulatin [...] | 0.911 |
GLI3 | GLI2 | ENSP00000379258 | ENSP00000354586 | GLI family zinc finger 3; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulatin [...] | GLI family zinc finger 2; Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5’-GAACCACCCA-3’ which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Is involved in the smoothened (SHH) signaling pathway | 0.911 |
GLI4 | MYCL1 | ENSP00000345024 | ENSP00000380494 | GLI family zinc finger 4 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | 0.459 |
HKR1 | MYCL1 | ENSP00000315505 | ENSP00000380494 | HKR1, GLI-Kruppel zinc finger family member; May be involved in transcriptional regulation | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | 0.483 |
KLF4 | MYCL1 | ENSP00000363804 | ENSP00000380494 | Kruppel-like factor 4 (gut); Transcription factor; can act both as activator and as repressor. Binds the 5’-CACCC-3’ core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may al [...] | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | 0.406 |
MAX | MXD1 | ENSP00000351490 | ENSP00000264444 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | MAX dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MAD thus antagonizes MYC transcriptional activity by competing for MAX | 0.999 |
MAX | MYCL1 | ENSP00000351490 | ENSP00000380494 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | 0.836 |
MAX | YY1 | ENSP00000351490 | ENSP00000262238 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | YY1 transcription factor; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repre [...] | 0.667 |
MAX | ZBTB17 | ENSP00000351490 | ENSP00000364895 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | zinc finger and BTB domain containing 17; Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during [...] | 0.954 |
MXD1 | MAX | ENSP00000264444 | ENSP00000351490 | MAX dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MAD thus antagonizes MYC transcriptional activity by competing for MAX | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | 0.999 |
MXD1 | MYCL1 | ENSP00000264444 | ENSP00000380494 | MAX dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MAD thus antagonizes MYC transcriptional activity by competing for MAX | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | 0.591 |
MYCL1 | GLI4 | ENSP00000380494 | ENSP00000345024 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | GLI family zinc finger 4 | 0.459 |
MYCL1 | HKR1 | ENSP00000380494 | ENSP00000315505 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | HKR1, GLI-Kruppel zinc finger family member; May be involved in transcriptional regulation | 0.483 |
MYCL1 | KLF4 | ENSP00000380494 | ENSP00000363804 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | Kruppel-like factor 4 (gut); Transcription factor; can act both as activator and as repressor. Binds the 5’-CACCC-3’ core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may al [...] | 0.406 |
MYCL1 | MAX | ENSP00000380494 | ENSP00000351490 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | 0.836 |
MYCL1 | MXD1 | ENSP00000380494 | ENSP00000264444 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | MAX dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MAD thus antagonizes MYC transcriptional activity by competing for MAX | 0.591 |
MYCL1 | RLF | ENSP00000380494 | ENSP00000361857 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | rearranged L-myc fusion; May be involved in transcriptional regulation | 0.753 |
MYCL1 | ZBTB48 | ENSP00000380494 | ENSP00000366902 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | zinc finger and BTB domain containing 48; Binds to and regulates the J and/or S elements in MHC II promoter | 0.483 |
MYCL1 | ZSCAN22 | ENSP00000380494 | ENSP00000332433 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | zinc finger and SCAN domain containing 22; May be involved in transcriptional regulation | 0.483 |