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FBL | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (321 aa) | |||
DDX55 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 55; Probable ATP-binding RNA helicase (600 aa) | |||
DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (547 aa) | |||
NOP58 | NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) (529 aa) | |||
CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa) | |||
MRPL3 | mitochondrial ribosomal protein L3 (348 aa) | |||
CPVL | carboxypeptidase, vitellogenic-like; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation (476 aa) | |||
RPL3L | ribosomal protein L3-like (407 aa) | |||
NHP2 | NHP2 ribonucleoprotein homolog (yeast); Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcr [...] (153 aa) | |||
TERT | telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3’-chromosomal termini with the 6- n [...] (1132 aa) | |||
PRPF31 | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) (499 aa) | |||
DDX24 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 24; ATP-dependent RNA helicase (Potential) (859 aa) | |||
SIRT7 | sirtuin 7; NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at ’Lys-18’ (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed pheno [...] (400 aa) | |||
UBC | ubiquitin C (685 aa) | |||
RPL3 | ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes (403 aa) | |||
RNF2 | ring finger protein 2; E3 ubiquitin-protein ligase that mediates monoubiquitination of ’Lys-119’ of histone H2A, thereby playing a central role in histone code and gene regulation. H2A ’Lys-119’ ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] (336 aa) | |||
DDX31 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 (851 aa) | |||
CTSA | cathepsin A; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins (498 aa) | |||
CSNK2B | casein kinase 2, beta polypeptide (215 aa) | |||
ENSG00000263020 | Lymphocyte antigen 6 complex, locus G5B (228 aa) | |||
RPP38 | ribonuclease P/MRP 38kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus (283 aa) | |||
NOP56 | NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa) | |||
DDX51 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits (By similarity) (666 aa) | |||
PWP1 | PWP1 homolog (S. cerevisiae); May play an important role in cell growth and/or transcription (501 aa) | |||
CPS1 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell (1506 aa) |