node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APPL1 | KIAA1468 | ENSP00000288266 | ENSP00000381198 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | KIAA1468 | 0.538 |
APPL1 | TTC4 | ENSP00000288266 | ENSP00000360329 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | tetratricopeptide repeat domain 4 | 0.538 |
CDC37L1 | HSP90B1 | ENSP00000371278 | ENSP00000299767 | cell division cycle 37 homolog (S. cerevisiae)-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (By similarity) | heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity | 0.901 |
CDC37L1 | KIAA1468 | ENSP00000371278 | ENSP00000381198 | cell division cycle 37 homolog (S. cerevisiae)-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (By similarity) | KIAA1468 | 0.538 |
CDC37L1 | TTC4 | ENSP00000371278 | ENSP00000360329 | cell division cycle 37 homolog (S. cerevisiae)-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (By similarity) | tetratricopeptide repeat domain 4 | 0.521 |
CDC37L1 | UBAP1 | ENSP00000371278 | ENSP00000441024 | cell division cycle 37 homolog (S. cerevisiae)-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (By similarity) | ubiquitin associated protein 1 | 0.538 |
CDC37L1 | USP25 | ENSP00000371278 | ENSP00000285679 | cell division cycle 37 homolog (S. cerevisiae)-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (By similarity) | ubiquitin specific peptidase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both ’Lys-48’- and ’Lys-63’-linked tetraubiquitin chains | 0.538 |
HSP90B1 | CDC37L1 | ENSP00000299767 | ENSP00000371278 | heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity | cell division cycle 37 homolog (S. cerevisiae)-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (By similarity) | 0.901 |
HSP90B1 | KIAA1468 | ENSP00000299767 | ENSP00000381198 | heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity | KIAA1468 | 0.538 |
HSP90B1 | TTC4 | ENSP00000299767 | ENSP00000360329 | heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity | tetratricopeptide repeat domain 4 | 0.892 |
HSP90B1 | USP25 | ENSP00000299767 | ENSP00000285679 | heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity | ubiquitin specific peptidase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both ’Lys-48’- and ’Lys-63’-linked tetraubiquitin chains | 0.538 |
KIAA1468 | APPL1 | ENSP00000381198 | ENSP00000288266 | KIAA1468 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | 0.538 |
KIAA1468 | CDC37L1 | ENSP00000381198 | ENSP00000371278 | KIAA1468 | cell division cycle 37 homolog (S. cerevisiae)-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (By similarity) | 0.538 |
KIAA1468 | HSP90B1 | ENSP00000381198 | ENSP00000299767 | KIAA1468 | heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity | 0.538 |
KIAA1468 | TTC4 | ENSP00000381198 | ENSP00000360329 | KIAA1468 | tetratricopeptide repeat domain 4 | 0.538 |
KIAA1468 | UBAP1 | ENSP00000381198 | ENSP00000441024 | KIAA1468 | ubiquitin associated protein 1 | 0.538 |
KIAA1468 | USP25 | ENSP00000381198 | ENSP00000285679 | KIAA1468 | ubiquitin specific peptidase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both ’Lys-48’- and ’Lys-63’-linked tetraubiquitin chains | 0.538 |
TTC4 | APPL1 | ENSP00000360329 | ENSP00000288266 | tetratricopeptide repeat domain 4 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | 0.538 |
TTC4 | CDC37L1 | ENSP00000360329 | ENSP00000371278 | tetratricopeptide repeat domain 4 | cell division cycle 37 homolog (S. cerevisiae)-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (By similarity) | 0.521 |
TTC4 | HSP90B1 | ENSP00000360329 | ENSP00000299767 | tetratricopeptide repeat domain 4 | heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity | 0.892 |