node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALM1 | CALM2 | ENSP00000349467 | ENSP00000272298 | calmodulin 1 (phosphorylase kinase, delta) | calmodulin 2 (phosphorylase kinase, delta) | 0.901 |
CALM1 | CRHR1 | ENSP00000349467 | ENSP00000381333 | calmodulin 1 (phosphorylase kinase, delta) | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.570 |
CALM1 | HSP90AA1 | ENSP00000349467 | ENSP00000335153 | calmodulin 1 (phosphorylase kinase, delta) | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.897 |
CALM2 | CALM1 | ENSP00000272298 | ENSP00000349467 | calmodulin 2 (phosphorylase kinase, delta) | calmodulin 1 (phosphorylase kinase, delta) | 0.901 |
CALM2 | CRHR1 | ENSP00000272298 | ENSP00000381333 | calmodulin 2 (phosphorylase kinase, delta) | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.569 |
CALM2 | HSP90AA1 | ENSP00000272298 | ENSP00000335153 | calmodulin 2 (phosphorylase kinase, delta) | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.497 |
CRH | CRHR1 | ENSP00000276571 | ENSP00000381333 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.999 |
CRH | GNAS | ENSP00000276571 | ENSP00000360141 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | 0.918 |
CRH | UCN | ENSP00000276571 | ENSP00000296099 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | urocortin; Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta | 0.980 |
CRHR1 | CALM1 | ENSP00000381333 | ENSP00000349467 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | calmodulin 1 (phosphorylase kinase, delta) | 0.570 |
CRHR1 | CALM2 | ENSP00000381333 | ENSP00000272298 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | calmodulin 2 (phosphorylase kinase, delta) | 0.569 |
CRHR1 | CRH | ENSP00000381333 | ENSP00000276571 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 0.999 |
CRHR1 | GNAI1 | ENSP00000381333 | ENSP00000343027 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.566 |
CRHR1 | GNAO1 | ENSP00000381333 | ENSP00000262493 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | 0.566 |
CRHR1 | GNAQ | ENSP00000381333 | ENSP00000286548 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.604 |
CRHR1 | GNAS | ENSP00000381333 | ENSP00000360141 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | 0.576 |
CRHR1 | SRPK1 | ENSP00000381333 | ENSP00000362931 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.461 |
CRHR1 | UCN | ENSP00000381333 | ENSP00000296099 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | urocortin; Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta | 0.998 |
CRHR1 | UCN3 | ENSP00000381333 | ENSP00000369798 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | urocortin 3 | 0.777 |
GNAI1 | CRHR1 | ENSP00000343027 | ENSP00000381333 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.566 |