Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | COL21A1 | collagen, type XXI, alpha 1 (957 aa) | ||
 | COL5A3 | collagen, type V, alpha 3; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1745 aa) | ||
 | COL14A1 | collagen, type XIV, alpha 1 (1796 aa) | ||
 | COL22A1 | collagen, type XXII, alpha 1; Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts (1626 aa) | ||
 | ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (798 aa) | ||
 | COL3A1 | collagen, type III, alpha 1 (1466 aa) | ||
 | COL9A1 | collagen, type IX, alpha 1 (921 aa) | ||
 | COL20A1 | collagen, type XX, alpha 1; Probable collagen protein (1284 aa) | ||
 | COL4A2 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1712 aa) | ||
 | COL6A1 | collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein (1028 aa) | ||
 | COL11A1 | collagen, type XI, alpha 1 (1806 aa) | ||
 | COL24A1 | collagen, type XXIV, alpha 1; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development (1714 aa) | ||
 | COL5A1 | collagen, type V, alpha 1; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1838 aa) | ||
 | COL4A6 | collagen, type IV, alpha 6 (1691 aa) | ||
 | COL9A2 | collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye (689 aa) | ||
 | COL16A1 | collagen, type XVI, alpha 1; Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology (1604 aa) | ||
 | COL5A2 | collagen, type V, alpha 2 (1499 aa) | ||
 | COL15A1 | collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle (1388 aa) | ||
 | COL4A1 | collagen, type IV, alpha 1; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1669 aa) | ||
 | COL2A1 | collagen, type II, alpha 1 (1487 aa) | ||
 | COL23A1 | collagen, type XXIII, alpha 1 (540 aa) | ||
 | COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) (1670 aa) | ||
 | COL4A4 | collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1690 aa) | ||
 | COL13A1 | collagen, type XIII, alpha 1 (717 aa) | ||
 | COL25A1 | collagen, type XXV, alpha 1; Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (654 aa) | ||
 | COL28A1 | collagen, type XXVIII, alpha 1; May act as a cell-binding protein (1125 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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