10 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain (296 aa)
	CD4	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts (458 aa)
	INS	insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) (110 aa)
	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1 (255 aa)
	UBC	ubiquitin C (685 aa)
	HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2 (255 aa)
	HLA-DRB5	major histocompatibility complex, class II, DR beta 5 (266 aa)
	HLA-DRA	major histocompatibility complex, class II, DR alpha (254 aa)
	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1 (261 aa)
	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1 (260 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	HLA-DQA1	ENSP00000011653	ENSP00000339398	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts	major histocompatibility complex, class II, DQ alpha 1	0.448
CD4	HLA-DQA2	ENSP00000011653	ENSP00000364076	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts	major histocompatibility complex, class II, DQ alpha 2	0.755
CD4	HLA-DQB1	ENSP00000011653	ENSP00000382034	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts	major histocompatibility complex, class II, DQ beta 1	0.863
CD4	INS	ENSP00000011653	ENSP00000250971	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts	insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity)	0.504
CD74	HLA-DPA1	ENSP00000009530	ENSP00000393566	CD74 molecule, major histocompatibility complex, class II invariant chain	major histocompatibility complex, class II, DP alpha 1	0.431
CD74	HLA-DQA1	ENSP00000009530	ENSP00000339398	CD74 molecule, major histocompatibility complex, class II invariant chain	major histocompatibility complex, class II, DQ alpha 1	0.744
CD74	HLA-DQA2	ENSP00000009530	ENSP00000364076	CD74 molecule, major histocompatibility complex, class II invariant chain	major histocompatibility complex, class II, DQ alpha 2	0.431
CD74	HLA-DQB1	ENSP00000009530	ENSP00000382034	CD74 molecule, major histocompatibility complex, class II invariant chain	major histocompatibility complex, class II, DQ beta 1	0.732
CD74	HLA-DRA	ENSP00000009530	ENSP00000378786	CD74 molecule, major histocompatibility complex, class II invariant chain	major histocompatibility complex, class II, DR alpha	0.744
CD74	HLA-DRB5	ENSP00000009530	ENSP00000364114	CD74 molecule, major histocompatibility complex, class II invariant chain	major histocompatibility complex, class II, DR beta 5	0.921
CD74	UBC	ENSP00000009530	ENSP00000344818	CD74 molecule, major histocompatibility complex, class II invariant chain	ubiquitin C	0.837
HLA-DPA1	CD74	ENSP00000393566	ENSP00000009530	major histocompatibility complex, class II, DP alpha 1	CD74 molecule, major histocompatibility complex, class II invariant chain	0.431
HLA-DQA1	CD4	ENSP00000339398	ENSP00000011653	major histocompatibility complex, class II, DQ alpha 1	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts	0.448
HLA-DQA1	CD74	ENSP00000339398	ENSP00000009530	major histocompatibility complex, class II, DQ alpha 1	CD74 molecule, major histocompatibility complex, class II invariant chain	0.744
HLA-DQA1	HLA-DQB1	ENSP00000339398	ENSP00000382034	major histocompatibility complex, class II, DQ alpha 1	major histocompatibility complex, class II, DQ beta 1	0.985
HLA-DQA1	HLA-DRB5	ENSP00000339398	ENSP00000364114	major histocompatibility complex, class II, DQ alpha 1	major histocompatibility complex, class II, DR beta 5	0.903
HLA-DQA1	UBC	ENSP00000339398	ENSP00000344818	major histocompatibility complex, class II, DQ alpha 1	ubiquitin C	0.683
HLA-DQA2	CD4	ENSP00000364076	ENSP00000011653	major histocompatibility complex, class II, DQ alpha 2	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts	0.755
HLA-DQA2	CD74	ENSP00000364076	ENSP00000009530	major histocompatibility complex, class II, DQ alpha 2	CD74 molecule, major histocompatibility complex, class II invariant chain	0.431
HLA-DQA2	HLA-DQB1	ENSP00000364076	ENSP00000382034	major histocompatibility complex, class II, DQ alpha 2	major histocompatibility complex, class II, DQ beta 1	0.674

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