node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | ESR2 | ENSP00000363822 | ENSP00000343925 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | estrogen receptor 2 (ER beta) | 0.921 |
AR | JMJD1C | ENSP00000363822 | ENSP00000382204 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | jumonji domain containing 1C | 0.614 |
AR | PPARG | ENSP00000363822 | ENSP00000287820 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | peroxisome proliferator-activated receptor gamma | 0.920 |
AR | THRB | ENSP00000363822 | ENSP00000348827 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | thyroid hormone receptor, beta; High affinity receptor for triiodothyronine | 0.910 |
AR | UBC | ENSP00000363822 | ENSP00000344818 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | ubiquitin C | 0.999 |
AR | VHL | ENSP00000363822 | ENSP00000256474 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 | 0.841 |
ESR2 | AR | ENSP00000343925 | ENSP00000363822 | estrogen receptor 2 (ER beta) | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.921 |
ESR2 | JMJD1C | ENSP00000343925 | ENSP00000382204 | estrogen receptor 2 (ER beta) | jumonji domain containing 1C | 0.483 |
ESR2 | PPARG | ENSP00000343925 | ENSP00000287820 | estrogen receptor 2 (ER beta) | peroxisome proliferator-activated receptor gamma | 0.962 |
ESR2 | THRB | ENSP00000343925 | ENSP00000348827 | estrogen receptor 2 (ER beta) | thyroid hormone receptor, beta; High affinity receptor for triiodothyronine | 0.913 |
ESR2 | UBC | ENSP00000343925 | ENSP00000344818 | estrogen receptor 2 (ER beta) | ubiquitin C | 0.824 |
JMJD1C | AR | ENSP00000382204 | ENSP00000363822 | jumonji domain containing 1C | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.614 |
JMJD1C | ESR2 | ENSP00000382204 | ENSP00000343925 | jumonji domain containing 1C | estrogen receptor 2 (ER beta) | 0.483 |
JMJD1C | PPARG | ENSP00000382204 | ENSP00000287820 | jumonji domain containing 1C | peroxisome proliferator-activated receptor gamma | 0.483 |
JMJD1C | RNF168 | ENSP00000382204 | ENSP00000320898 | jumonji domain containing 1C | ring finger protein 168, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8- dependent H2A ubiquitination, promoting the formation of ’Lys-63’- linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 an [...] | 0.575 |
JMJD1C | RNF8 | ENSP00000382204 | ENSP00000362578 | jumonji domain containing 1C | ring finger protein 8, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles- by mediating the ’Lys-63’- linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing ’Lys-48’-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the ’Lys-63’-linked ubiquitination of histones H2A and H2AX, thereby promoting th [...] | 0.592 |
JMJD1C | RXRA | ENSP00000382204 | ENSP00000419692 | jumonji domain containing 1C | retinoid X receptor, alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response [...] | 0.695 |
JMJD1C | THRB | ENSP00000382204 | ENSP00000348827 | jumonji domain containing 1C | thyroid hormone receptor, beta; High affinity receptor for triiodothyronine | 0.720 |
JMJD1C | UBC | ENSP00000382204 | ENSP00000344818 | jumonji domain containing 1C | ubiquitin C | 0.684 |
PPARG | AR | ENSP00000287820 | ENSP00000363822 | peroxisome proliferator-activated receptor gamma | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.920 |