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BRD1 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (1058 aa) | |||
NANOG | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] (305 aa) | |||
PCGF1 | polycomb group ring finger 1; Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell prolifer [...] (259 aa) | |||
MAGEA10 | melanoma antigen family A, 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression (369 aa) | |||
FBXO31 | F-box protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor (539 aa) | |||
FAM170A | family with sequence similarity 170, member A (329 aa) | |||
HNRNPH2 | heterogeneous nuclear ribonucleoprotein H2 (H’); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (449 aa) | |||
FHL3 | four and a half LIM domains 3 (280 aa) | |||
QSER1 | glutamine and serine rich 1 (1735 aa) |