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FBL | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (321 aa) | |||
RBM28 | RNA binding motif protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes (759 aa) | |||
DDX55 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 55; Probable ATP-binding RNA helicase (600 aa) | |||
NIP7 | nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly (180 aa) | |||
WDR12 | WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (423 aa) | |||
NOP58 | NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) (529 aa) | |||
MKI67IP | MKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa) | |||
NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter (749 aa) | |||
RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); Involved in ribosome biogenesis (By similarity) (365 aa) | |||
DDX54 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (882 aa) | |||
RPL7 | ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (248 aa) | |||
GTPBP4 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) (634 aa) | |||
RPL5 | ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA (297 aa) | |||
RPF1 | ribosome production factor 1 homolog (S. cerevisiae); May be required for ribosome biogenesis (349 aa) | |||
NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae); May be required for adipogenesis (By similarity) (800 aa) | |||
DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (796 aa) | |||
EIF6 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity (245 aa) | |||
RPL11 | ribosomal protein L11; Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity) (178 aa) | |||
MRTO4 | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) (239 aa) | |||
NOP56 | NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa) | |||
NOP2 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase (808 aa) | |||
RPL23A | ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity) (156 aa) | |||
GNL3 | guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity) (549 aa) | |||
FTSJ3 | FtsJ homolog 3 (E. coli); Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation (847 aa) | |||
RPF2 | ribosome production factor 2 homolog (S. cerevisiae) (306 aa) | |||
EBNA1BP2 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) (361 aa) |